The Emerging Role of SIRT7 in Glucose and Lipid Metabolism

被引：6
|
作者：
Yamagata, Kazuya [1 ,2 ]
Mizumoto, Tomoya [1 ]
Yoshizawa, Tatsuya [1 ]
机构：
[1] Kumamoto Univ, Fac Life Sci, Dept Med Biochem, Kumamoto 8608556, Japan
[2] Kumamoto Univ, Fac Life Sci, Ctr Metab Regulat Hlth Aging, Kumamoto 8608556, Japan
来源：
CELLS | 2024年 / 13卷 / 01期
关键词：
sirtuin; SIRT7; SIRT1; SIRT6; diabetes; obesity; DIET-INDUCED OBESITY; RNA-POLYMERASE-I; ADIPOSE-TISSUE; INSULIN-RESISTANCE; DEACETYLASE SIRT6; SIRT7-DEPENDENT DEACETYLATION; DEPENDENT DEACETYLATION; FAT MOBILIZATION; MAMMALIAN SIR2; BROWN;
D O I：
10.3390/cells13010048
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sirtuins (SIRT1-7 in mammals) are a family of NAD+-dependent lysine deacetylases and deacylases that regulate diverse biological processes, including metabolism, stress responses, and aging. SIRT7 is the least well-studied member of the sirtuins, but accumulating evidence has shown that SIRT7 plays critical roles in the regulation of glucose and lipid metabolism by modulating many target proteins in white adipose tissue, brown adipose tissue, and liver tissue. This review focuses on the emerging roles of SIRT7 in glucose and lipid metabolism in comparison with SIRT1 and SIRT6. We also discuss the possible implications of SIRT7 inhibition in the treatment of metabolic diseases such as type 2 diabetes and obesity.
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收藏
页数：14
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