A snap-through instability of cell adhesion under perturbations in hydrostatic pressure

被引：0

作者：

Liu, Shaobao ^{[1
,2
]}

Yang, Haiqian ^{[4
]}

Xu, Guang-Kui ^{[5
]}

Wu, Jingbo ^{[1
,2
]}

Tao, Ru ^{[3
,4
]}

Wang, Meng ^{[3
,4
]}

He, Rongyan ^{[3
,4
]}

Han, Yulong ^{[1
,2
]}

Genin, Guy M. ^{[3
,4
,6
]}

Lu, Tian Jian ^{[1
,2
]}

Xu, Feng ^{[3
,4
]}

机构：

[1] Nanjing Univ Aeronaut & Astronaut, State Key Lab Mech & Control Aerosp Struct, Nanjing 210016, Peoples R China

[2] Nanjing Univ Aeronaut & Astronaut, MIIT Key Lab Multifunct Lightweight Mat & Struct, Nanjing 210016, Peoples R China

[3] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Key Lab Biomed Informat Engn, Minist Educ, Xian 710049, Peoples R China

[4] Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr BEBC, Xian 710049, Shaanxi, Peoples R China

[5] Xi An Jiao Tong Univ, Int Ctr Appl Mech, Sch Aerosp, State Key Lab Strength & Vibrat Mech Struct, Xian 710049, Peoples R China

[6] Washington Univ, Natl Sci Fdn Sci & Technol Ctr Engn Mechanobiol, St Louis, MO 63130 USA

来源：

JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS | 2024年 / 182卷

基金：

中国国家自然科学基金;

关键词：

Tumor microenvironment; Metastasis; Bistability; Morphology; Mechanomedicine; VOLUME REGULATION; SHEAR-STRESS; MICROENVIRONMENT; INTEGRIN; RELEASE; TENSION; DEATH; SHAPE;

D O I：

10.1016/j.jmps.2023.105476

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The balance between stress and adhesion governs many behaviors of adherent cells such as cell migration. In certain microenvironments such as that of a tumor, variations in hydrostatic pressure be substantial compared to cell-generated stresses. These variations can affect stressactivated ion channels whose activation can in turn affect cell volume and adhesion. To study these effects, we developed a theoretical model to relate changes in hydrostatic pressure to the morphology and volume of adherent cells. The model predicted the bistability of cell morphology (i.e., a snap-through instability) under hydrostatic pressure for certain ranges of adhesion energy density. This snap-through instability can enable cells to spontaneously detach from their environment, and may have bearing on migration and metastasis.

引用

页数：10

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