Hemophagocytic Lymphohistiocytosis: A Rare Complication of COVID-19 in a Patient With Sickle Cell Anemia

被引：0

作者：

Al-Handola, Rami ^{[1
]}

Abdelkader, Khaled ^{[2
]}

Karrar, Arif ^{[1
]}

Chinnappan, Justine ^{[1
]}

Rode, Geeta ^{[3
]}

机构：

[1] Michigan State Univ, Coll Human Med, Hurley Med Ctr, Internal Med, Flint, MI 48824 USA

[2] Royal Berkshire Hosp, Gen Med, Reading, England

[3] Michigan State Univ, Coll Human Med, Hurley Med Ctr, Flint, MI USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 10期

关键词：

covid-19; sars-cov-2 associated hlh; secondary hlh; secondary hemophagocytic lymphohistiocytosis (hlh); adult sickle cell anemia; hemophagocytic lymphohistiocytosis (hlh); hlh;

D O I：

10.7759/cureus.47631

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon condition that can be fatal due to overwhelming macrophage activation and cytokine production. It can be primary (familial/genetic) or secondary. It is associated with infections, malignancies, and rheumatologic and immunodeficiency disorders. We report a middle-aged female patient with sickle cell anemia who presented with COVID-19 infection that triggered a vaso-occlusive crisis and resulted in HLH. She had preexisting high ferritin levels and cytopenias, making the diagnosis more challenging. A high index of suspicion and timely treatment is essential to prevent adverse outcomes.

引用

页数：4

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