Recent studies increasingly highlight involvement of the cerebellum in drug craving and addiction. However, its exact role, that is, whether the cerebellum is a critical component of a brain network underlying addictive behaviour, or whether it rather is a facilitator or mediator, is still unclear. Findings concerning the newly recognized internet gaming disorder (IGD) suggest that changes in cerebellar connectivity and functioning are associated with behavioural/non-substance addiction. Here, we systematically review the literature on IGD and cerebellar involvement following the PRISMA guidelines. A total of 13 neuroimaging studies met the inclusion criteria. Studies utilized a broad range of diagnostic instruments and resulting cut-off criteria, rendering it difficult to compare findings. Results on altered cerebro-cerebellar connectivity in patients with IGD are mixed; most studies report altered or increased functional connectivity. Moreover, decreased cerebellar grey matter volume is reported. Studies have further indicated that differential activation patterns in the cerebellum may enable discrimination between healthy subjects and subjects with IGD, even allowing for prediction of treatment outcomes. Given the strong connectivity between the cerebellum and cerebral regions, the cerebellum may act as an intermediary between regions involved in craving and addiction and consequently affect symptoms of IGD. Results suggest differential involvement of the cerebellar lobes, emphasizing a need for high-resolution parcellation of the cerebellum in future studies. However, the studies included in the present review have small sample sizes and include mostly male participants. Thus, results may have limited generalizability yet highlight a crucial role of the cerebellum in IGD that needs further investigation. A systematic integration of the existing literature highlights altered cerebro-cerebellar connectivity and decreased cerebellar grey matter volume in patients with internet gaming disorder. Furthermore, studies indicate that differential activation patterns in the cerebellum may enable the discrimination between healthy subjects and subjects with internet gaming disorder. Resulting evidence suggests differential involvement of the cerebellar lobes in this disorder.image
机构:
Yokohama City Univ, Sch Med, Unit Publ Hlth & Prevent Med, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, JapanYokohama City Univ, Sch Med, Unit Publ Hlth & Prevent Med, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan
Sugaya, Nagisa
Shirasaka, Tomohiro
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机构:
Teine Keijinkai Hosp, Dept Psychiat, Teine Ku, 1-12-1-40 Maeda, Sapporo, Hokkaido 0068555, JapanYokohama City Univ, Sch Med, Unit Publ Hlth & Prevent Med, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan
Shirasaka, Tomohiro
Takahashi, Kenzo
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Teikyo Univ, Grad Sch Publ Hlth, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, JapanYokohama City Univ, Sch Med, Unit Publ Hlth & Prevent Med, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan
机构:
Department of Psychiatry, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung
Department of Psychiatry, Faculty of Medicine and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, KaohsiungDepartment of Psychiatry, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung