Evaluation of PD-L1 as a biomarker for immunotherapy for hepatocellular carcinoma: systematic review and meta-analysis

被引：6
|
作者：
Zhou, Xueyin [1 ,2 ]
Cao, Jiasheng [2 ,3 ]
Topatana, Win [3 ]
Xie, Tianao [4 ]
Chen, Tianen [2 ,3 ]
Hu, Jiahao [2 ,3 ]
Li, Shijie [2 ,3 ]
Juengpanic, Sarun [3 ]
Lu, Ziyi [3 ,5 ]
Zhang, Bin [2 ,3 ]
Wang, Kaitai [1 ]
Feng, Xu [2 ,3 ]
Shen, Jiliang [2 ,3 ]
Chen, Mingyu [2 ,3 ]
机构：
[1] Wenzhou Med Univ, Sch Med, Wenzhou 325035, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Gen Surg, Hangzhou 310016, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
[4] Guangzhou Med Univ, Clin Sch 3, Dept Clin Med, Guangzhou 511436, Peoples R China
[5] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China
来源：
IMMUNOTHERAPY | 2023年 / 15卷 / 05期
关键词：
biomarker; hepatocellular carcinoma; meta-analysis; PD-L1; systematic review; UROTHELIAL CARCINOMA; EXPRESSION; ATEZOLIZUMAB; MULTICENTER;
D O I：
10.2217/imt-2022-0168
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aim:To determine if PD-L1 can be used as a biomarker to predict the efficacy of anti-PD-1/PD-L1 inhibitors in hepatocellular carcinoma (HCC). Methods:Relevant studies from a specific search of the four databases from October 2014 to December 2022 were included in this meta-analysis. Results:Higher PD-L1 expression levels were associated with a higher objective response rate (ORR). Higher PD-L1 expression levels on tumor cells and tumor proportion score were associated with higher ORR. PD-L1 was capable of predicting the effectiveness of nivolumab. Dako 28-8 is a promising assay for HCC. Conclusion:PD-L1 is a predictive biomarker for ORR in HCC. Tumor proportion score and PD-L1 expression levels on tumor cells are potential scoring algorithms.
引用
下载
收藏
页码：353 / 365
页数：13
相关论文
共 50 条
  • [21] The prognostic significance of PD-L1 and PD-1 expression in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis
    Zi-Lu Huang
    Shan Liu
    Guan-Nan Wang
    Shuo-Han Zheng
    Shi-Rong Ding
    Ya-lan Tao
    Chen Chen
    Song-Ran Liu
    Xin Yang
    Hui Chang
    Xiao-Hui Wang
    Yun-Fei Xia
    Cancer Cell International, 19
  • [22] The prognostic significance of PD-L1 and PD-1 expression in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis
    Huang, Zi-Lu
    Liu, Shan
    Wang, Guan-Nan
    Zheng, Shuo-Han
    Ding, Shi-Rong
    Tao, Ya-lan
    Chen, Chen
    Liu, Song-Ran
    Yang, Xin
    Chang, Hui
    Wang, Xiao-Hui
    Xia, Yun-Fei
    CANCER CELL INTERNATIONAL, 2019, 19 (1)
  • [23] The Prognostic Significance of PD-L1 and PD-1 Expression in Patients with Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis
    Huang, Z.
    Shan, L.
    Zheng, S. H.
    Wang, G.
    Ding, S. R.
    Tao, Y. L.
    Chen, C.
    Yang, X.
    Liu, S. R.
    Xia, Y.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2019, 105 (01): : E437 - E437
  • [24] PD-L1 expression as biomarker of efficacy of PD-1/PD-L1 checkpoint inhibitors in metastatic triple negative breast cancer: A systematic review and meta-analysis
    Khan, Muhammad
    Du, Kunpeng
    Ai, Meiling
    Wang, Baiyao
    Lin, Jie
    Ren, Anbang
    Chen, Chengcong
    Huang, Zhong
    Qiu, Wenze
    Yuan, Yawei
    Tian, Yunhong
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [25] Neoadjuvant immunotherapy for resectable hepatocellular carcinoma: a systematic review and meta-analysis
    Han, Y. -H.
    Bo, J. -Q.
    Liu, L. -X.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2023, 27 (15) : 7134 - 7147
  • [26] The benefit of immunotherapy in patients with hepatocellular carcinoma: a systematic review and meta-analysis
    Guven, Deniz Can
    Erul, Enes
    Sahin, Taha Koray
    Dizdar, Omer
    Yalcin, Suayib
    Sahin, Ibrahim Halil
    FUTURE ONCOLOGY, 2022, 18 (37) : 4119 - 4136
  • [27] PD-1 inhibitors monotherapy in hepatocellular carcinoma: Meta-analysis and systematic review
    Ioannis A.Voutsadakis
    Hepatobiliary & Pancreatic Diseases International, 2019, 18 (06) : 505 - 510
  • [28] PD-1 inhibitors monotherapy in hepatocellular carcinoma: Meta-analysis and systematic review
    Voutsadakis, Ioannis A.
    HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 2019, 18 (06) : 505 - 510
  • [29] Prevalence and prognostic value of PD-L1 expression in medullary thyroid carcinoma: a systematic review and meta-analysis
    Torresani, E.
    Girolami, I.
    Colato, C.
    Brazzarola, P.
    Castello, R.
    Trimboli, P.
    Bongiovanni, M.
    Pantanowitz, L.
    Scarpa, A.
    Brunelli, M.
    Eccher, A.
    VIRCHOWS ARCHIV, 2020, 477 : S289 - S289
  • [30] Prognostic role of PD-L1 expression in renal cell carcinoma. A systematic review and meta-analysis
    Nole, F.
    Iacovelli, R.
    Verri, E.
    Renne, G.
    Paglino, C.
    Santoni, M.
    Rocca, M. Cossu
    Giglione, P.
    Aurilio, G.
    Cullura, D.
    Cascinu, S.
    Porta, C.
    ANNALS OF ONCOLOGY, 2015, 26 : 58 - 58
12345