Presence of Small-Conductance Calcium-Activated Potassium (SK) Channels in the Central and Peripheral Nervous Systems and Their Role in Health and Disease

被引:2
|
作者
DosSantos, Marcos Fabio [1 ,2 ,3 ,4 ]
Acosta Filha, Lionete Gall Acosta [1 ,2 ,3 ]
Verissimo, Carla Pires [1 ,2 ]
Sanz, Carolina Kaminski [1 ]
Gazerani, Parisa [5 ,6 ]
机构
[1] Univ Fed Rio de Janeiro UFRJ, Fac Odontol, Dept Protese & Mat Dentarios, Lab Propriedades Mecan & Biol Celular PropBio, BR-21941617 Rio de Janeiro, Brazil
[2] Univ Fed Rio de Janeiro UFRJ, Lab Morfogenese Celular LMC, Inst Ciencias Biomed ICB, BR-21941590 Rio de Janeiro, Brazil
[3] Inst Nacl Neurociencia Translac INNT UFRJ, Programa Pos Graduacao Neurociencia Translac, BR-21941590 Rio de Janeiro, Brazil
[4] Univ Fed Rio de Janeiro UFRJ, Programa Pos Graduacao Odontol PPGO, BR-21941617 Rio de Janeiro, Brazil
[5] Oslo Metropolitan Univ, Fac Hlth Sci, Dept Life Sci & Hlth, N-0130 Oslo, Norway
[6] Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, DK-9260 Gistrup, Denmark
关键词
calcium-activated potassium channels; small-conductance calcium-activated potassium channels; SK channels; pain; noci-ception; central nervous system; peripheral nervous system; CA2+-ACTIVATED K+ CHANNELS; SATELLITE GLIAL-CELLS; SYNAPTIC-TRANSMISSION; TRIGEMINAL GANGLION; AFTER-HYPERPOLARIZATION; MOLECULAR DETERMINANTS; FUNCTIONAL EXPRESSION; EXCITABILITY CONTROL; NEUROPATHIC PAIN; SENSORY NEURONS;
D O I
10.31083/j.jin2203069
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Potassium (K+) channels establish and maintain the resting potential of most living cells. Their activity is predominantly regulated by the membrane voltage or the K+ gradient across the cell membrane. However, many cells also express small-conductance calcium activated potassium (SK) channels, which have the unique ability to translate changes in the level of the intracellular second messenger, Ca2+ to changes in the membrane K+ conductance and, therefore, the resting membrane potential. This article reviews the structure, presence, distribution, and function of SK channels, their pharmacological modulation, and their role in health and disease, emphasizing nociception and pain.
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收藏
页数:14
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