Engineering CRISPR/Cas-based nanosystems for therapeutics, diagnosis and bioimaging

被引:8
|
作者
Song, Nachuan [1 ]
Li, Shuai [1 ,2 ]
Lv, Zhaoyue [1 ]
Ding, Xiaohui [1 ]
Li, Feng [1 ]
Yang, Dayong [1 ,2 ]
机构
[1] Tianjin Univ, Inst Biomol & Biomed Engn, Frontiers Sci Ctr Synthet Biol, Sch Chem Engn & Technol,Key Lab Syst Bioengn MOE, Tianjin 300350, Peoples R China
[2] Tianjin Univ, Zhejiang Inst, Ningbo 315201, Peoples R China
基金
中国国家自然科学基金;
关键词
CRISPR/Cas; DNA nanotechnology; DNA nanomaterials; Cancer therapy; Diagnosis; Bioimaging; NUCLEIC-ACID DETECTION; SENSITIVE DETECTION; GENOMIC LOCI; CAS SYSTEMS; DNA; RNA; DELIVERY; GENE; AMPLIFICATION; ENDONUCLEASE;
D O I
10.1016/j.cclet.2023.108134
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
CRISPR/Cas system has been utilized to rationally manipulate intracellular genes, and it has been engineered as versatile and efficient gene editing tools with precise site-specificity and excellent targeting ability for therapeutics, diagnostics, and bioimaging. Here, the evolution and application of CRISPR/Cas systems were sketched chronologically. Landmark works were exemplified to illustrate the design principles of CRISPR/Cas systems. Furthermore, the delivery vectors of CRISPR/Cas system especially DNA nanomaterials-based vectors were categorized and illuminated. DNA nanomaterials are suitable for CRISPR/Cas system delivery via base pairing due to its sequence programmability and biocompatibility. Then the applications of CRISPR/Cas in diagnosis and genomic imaging were highlighted. At the end of the review, the challenges and opportunities of CRISPR/Cas systems were deeply discussed. We envision that the grant advances on CRISPR/Cas systems will promote the development of interdisciplinary fields in chemistry, biology and medicine.& COPY; 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
引用
收藏
页数:9
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