Response to selpercatinib in a patient with RET fusion-positive pulmonary large-cell neuroendocrine carcinoma: A case report

被引：5

作者：

Arora, Aakriti ^{[1
]}

Zaemes, Jacob ^{[2
]}

Ozdemirli, Metin ^{[3
]}

Kim, Chul ^{[2
]}

机构：

[1] MedStar Washington Hosp Ctr, Dept Med, Washington, DC USA

[2] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA

[3] MedStar Georgetown Univ Hosp, Dept Pathol, Washington, DC USA

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

关键词：

RET fusion; large cell neuroendocrine carcinoma; selpercatinib; lung cancer (LC); targeted; LUNG-CARCINOMA; FEATURES;

D O I：

10.3389/fonc.2023.1134151

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Large-cell neuroendocrine carcinoma (LCNEC) is a rare subtype of non-small-cell lung cancer associated with a poor prognosis. LCNEC is genetically heterogeneous, and studies have revealed distinct molecular subtypes of LCNEC, which may have therapeutic implications. Herein, we present a case of a patient with stage IV LCNEC harboring a KIF5B-RET fusion whose disease responded to the selective RET inhibitor selpercatinib both extra- and intra-cranially, highlighting the importance of comprehensive molecular testing in LCNEC for selection of optimal treatment.

引用

页数：5

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