Response to selpercatinib in a patient with RET fusion-positive pulmonary large-cell neuroendocrine carcinoma: A case report

被引：5
|
作者：
Arora, Aakriti [1 ]
Zaemes, Jacob [2 ]
Ozdemirli, Metin [3 ]
Kim, Chul [2 ]
机构：
[1] MedStar Washington Hosp Ctr, Dept Med, Washington, DC USA
[2] Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA
[3] MedStar Georgetown Univ Hosp, Dept Pathol, Washington, DC USA
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
RET fusion; large cell neuroendocrine carcinoma; selpercatinib; lung cancer (LC); targeted; LUNG-CARCINOMA; FEATURES;
D O I：
10.3389/fonc.2023.1134151
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Large-cell neuroendocrine carcinoma (LCNEC) is a rare subtype of non-small-cell lung cancer associated with a poor prognosis. LCNEC is genetically heterogeneous, and studies have revealed distinct molecular subtypes of LCNEC, which may have therapeutic implications. Herein, we present a case of a patient with stage IV LCNEC harboring a KIF5B-RET fusion whose disease responded to the selective RET inhibitor selpercatinib both extra- and intra-cranially, highlighting the importance of comprehensive molecular testing in LCNEC for selection of optimal treatment.
引用
收藏
页数：5
相关论文
共 50 条
  • [1] First-line selpercatinib for a patient with RET fusion-positive pulmonary large cell neuroendocrine carcinoma
    Eihuku, Tatsuru
    Miwa, Seiichi
    Oshima, Tomoko
    Ohba, Hisano
    Shirai, Masahiro
    [J]. RESPIRATORY MEDICINE CASE REPORTS, 2024, 52
  • [2] Lazarus Response to Selpercatinib for Bleeding Colic Metastasis in a Patient With RET Fusion- Positive Pulmonary Sarcomatoid Carcinoma: A Case Report
    Monaca, Federico
    Vita, Emanuele
    Lococo, Filippo
    Tortora, Giampaolo
    Bria, Emilio
    [J]. CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (07)
  • [3] Rapid response to selpercatinib in RET fusion positive pancreatic neuroendocrine carcinoma confirmed by smartwatch
    Deschler-Baier, Barbara
    Krebs, Markus
    Kroiss, Matthias
    Chatterjee, Manik
    Gundel, Daniel
    Kestler, Christian
    Kerscher, Alexander
    Kunzmann, Volker
    Appenzeller, Silke
    Maurus, Katja
    Rosenwald, Andreas
    Bargou, Ralf
    Gerhard-Hartmann, Elena
    Venkataramani, Vivek
    [J]. NPJ PRECISION ONCOLOGY, 2024, 8 (01)
  • [4] Successful radioiodine redifferentiation with selpercatinib in RET fusion-positive papillary thyroid carcinoma
    Weiler, Daniela
    Lago, Maria del Sol Perez
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2024, 51 (11) : 3467 - 3468
  • [5] Response to the Selective RET Inhibitor Selpercatinib (LOXO-292) in a Patient With RET Fusion-positive Atypical Lung Carcinoid
    Kander, Elizabeth M.
    Shah, Manisha H.
    Zhou, Ye
    Goyal, Ashima
    Palmer, Joshua D.
    Owen, Dwight H.
    Shilo, Konstantin
    Patel, Gopal
    Raval, Raju R.
    Gonzalez, Javier
    Nguyen, Michele
    Olek, Elizabeth
    Kherani, Jennifer
    Rothenberg, S. Michael
    Konda, Bhavana
    [J]. CLINICAL LUNG CANCER, 2021, 22 (03) : E442 - E445
  • [6] Complete Response to Selective RET Inhibition With Selpercatinib (LOXO-292) in a Patient With RET Fusion-Positive Breast Cancer
    Watanabe, Satomi
    Takeda, Masayuki
    Otani, Tomoyuki
    Yoshida, Takeshi
    Sakai, Kazuko
    Olek, Elizabeth
    Rothenberg, S. Michael
    Kherani, Jennifer
    French, Pearl P.
    Nishio, Kazuto
    Ito, Akihiko
    Nakagawa, Kazuhiko
    [J]. JCO PRECISION ONCOLOGY, 2021, 5 : 103 - 106
  • [7] Primary Resistance to RET Inhibition in a RET Fusion-Positive Pancreatic Neuroendocrine Carcinoma
    Mckinley, Blake J.
    Coston, Tucker W.
    Starr, Jason S.
    [J]. ONCOLOGIST, 2024,
  • [8] Neoadjuvant immunochemotherapy for pulmonary large-cell neuroendocrine carcinoma: case report
    Xu, Chang
    Zhao, Guangyin
    Zhang, Hongyu
    Ge, Di
    Gu, Jie
    [J]. JOURNAL OF CARDIOTHORACIC SURGERY, 2024, 19 (01)
  • [9] Complete response to selpercatinib (LOXO-292), a highly selective RET inhibitor, in a patient with RET fusion-positive breast cancer
    Takeda, Masayuki
    Watanabe, Satomi
    Rothenberg, S. Michael
    Kherani, Jennifer
    French, Pearl P.
    Olek, Elizabeth
    [J]. CANCER RESEARCH, 2020, 80 (16)
  • [10] Case Report: Complete pathologic response to neoadjuvant selpercatinib in a patient with resectable early-stage RET fusion-positive non-small cell lung cancer
    Goldman, Jonathan W.
    Sholl, Lynette M.
    Dacic, Sanja
    Fishbein, Michael C.
    Murciano-Goroff, Yonina R.
    Rajaram, Ravi
    Szymczak, Sylwia
    Szpurka, Anna M.
    Chao, Bo H.
    Drilon, Alexander
    [J]. FRONTIERS IN ONCOLOGY, 2023, 13
12345