Expression, regulating mechanism and therapeutic target of KIF20A in multiple cancer

被引：22
|
作者：
Jin, Zheng [1 ]
Peng, Fei [2 ]
Zhang, Chao [3 ]
Tao, Shuang [4 ]
Xu, Damo [1 ,5 ]
Zhu, Zhenhua [6 ]
机构：
[1] Shenzhen Univ, Dept Respirol & Allergy, Affiliated Hosp 3, Shenzhen, Guangdong, Peoples R China
[2] Baylor Coll Med, Dept Med, Div Endocrinol Diabet & Metab, Houston, TX USA
[3] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Clin Res Ctr Child Hlth, Guangzhou, Guangdong, Peoples R China
[4] Guangzhou Univ Chinese Med, Longgang Cent Hosp Shenzhen, Dept Otorhinolaryngology Head & Neck Surg, Guangzhou, Guangdong, Peoples R China
[5] Shenzhen Univ, Sch Med, Shenzhen Key Lab Allergy & Immunol, State Key Lab Resp Dis Allergy, Shenzhen, Guangdong, Peoples R China
[6] Southern Med Univ, Dept Orthpaed Trauma, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China
来源：
HELIYON | 2023年 / 9卷 / 02期
关键词：
KIF20A; Cancer; Expression; Regulating mechanisms; Therapeutic target; CLEAR-CELL CARCINOMA; II CLINICAL-TRIAL; FAMILY-MEMBER; 20A; COLORECTAL-CANCER; GASTRIC-CANCER; SUPERFAMILY PROTEINS; DOWN-REGULATION; POOR-PROGNOSIS; UP-REGULATION; KINESIN;
D O I：
10.1016/j.heliyon.2023.e13195
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Kinesin family member 20A (KIF20A) is a member of the kinesin family. It transports chromo-somes during mitosis, plays a key role in cell division. Recently, studies proved that KIF20A was highly expressed in cancer. High expression of KIF20A was correlated with poor overall survival (OS). In this review, we summarized all the cancer that highly expressed KIF20A, described the role of KIF20A in cancer. We also organized phase I and phase II clinical trials of KIF20A peptides vaccine. All results indicated that KIF20A was a promising therapeutic target for multiple cancer.
引用
收藏
页数：16
相关论文
共 50 条
  • [21] Identification and validation of KIF20A for predicting prognosis and treatment outcomes in patients with breast cancer
    Yang, Mei
    Huang, Hui
    Zhang, Yan
    Wang, Yiping
    Zhao, Junhao
    Lee, Peiyao
    Ma, Yuhua
    Qu, Shaohua
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [22] Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
    Runxiang Qiu
    Jun Wu
    Brian Gudenas
    Paul A. Northcott
    Robert J. Wechsler-Reya
    Qiang Lu
    Communications Biology, 4
  • [23] CBX3 contributes to pancreatic adenocarcinoma progression via promoting KIF20A expression
    Wang, Xiaohui
    Meng, Ping
    Liu, Huili
    Tan, Jinhua
    Liu, Yu
    Li, Xu
    CYTOTECHNOLOGY, 2025, 77 (01)
  • [24] Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
    Qiu, Runxiang
    Wu, Jun
    Gudenas, Brian
    Northcott, Paul A.
    Wechsler-Reya, Robert J.
    Lu, Qiang
    COMMUNICATIONS BIOLOGY, 2021, 4 (01)
  • [25] FOXM1 regulates radiosensitivity of lung cancer cell partly by upregulating KIF20A
    Xiu, Guanghong
    Sui, Xiujie
    Wang, Yirong
    Zhang, Ze
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 833 : 79 - 85
  • [26] Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer
    Mbugua, Regina Wachuka
    Takano, Atsushi
    Tsevegjav, Bayarbat
    Yokose, Tomoyuki
    Yamashita, Toshinari
    Miyagi, Yohei
    Daigo, Yataro
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2024, 64 (04)
  • [27] Ginsenoside 20(S)-Rg3 reduces KIF20A expression and promotes CDC25A proteasomal degradation in epithelial ovarian cancer
    Zhang, Rong
    Li, Lei
    Li, Huihui
    Bai, Hansong
    Suo, Yuping
    Cui, Ju
    Wang, Yingmei
    JOURNAL OF GINSENG RESEARCH, 2024, 48 (01) : 40 - 51
  • [28] Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study
    Yan, Guang-Rong
    Zou, Fei-Yan
    Dang, Bian-Li
    Zhang, Ye
    Yu, Guangchuang
    Liu, Xiao
    He, Qing-Yu
    PROTEOMICS, 2012, 12 (14) : 2391 - 2399
  • [29] KIF20B Promotes Cell Proliferation and May Be a Potential Therapeutic Target in Pancreatic Cancer
    Chen, Jing
    Zhao, Cui-Cui
    Chen, Fei-Ran
    Feng, Guo-Wei
    Luo, Fei
    Jiang, Tao
    JOURNAL OF ONCOLOGY, 2021, 2021
  • [30] Paper Low expression of KIF20A suppresses cell proliferation, promotes chemosensitivity and is associated with better prognosis in HCC
    Wu, Chuanxing
    Qi, Xiaosheng
    Qiu, Zhengjun
    Deng, Guilong
    Zhong, Lin
    AGING-US, 2021, 13 (18): : 22148 - 22163
12345