Expression, regulating mechanism and therapeutic target of KIF20A in multiple cancer

被引：24
|
作者：
Jin, Zheng [1 ]
Peng, Fei [2 ]
Zhang, Chao [3 ]
Tao, Shuang [4 ]
Xu, Damo [1 ,5 ]
Zhu, Zhenhua [6 ]
机构：
[1] Shenzhen Univ, Dept Respirol & Allergy, Affiliated Hosp 3, Shenzhen, Guangdong, Peoples R China
[2] Baylor Coll Med, Dept Med, Div Endocrinol Diabet & Metab, Houston, TX USA
[3] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Clin Res Ctr Child Hlth, Guangzhou, Guangdong, Peoples R China
[4] Guangzhou Univ Chinese Med, Longgang Cent Hosp Shenzhen, Dept Otorhinolaryngology Head & Neck Surg, Guangzhou, Guangdong, Peoples R China
[5] Shenzhen Univ, Sch Med, Shenzhen Key Lab Allergy & Immunol, State Key Lab Resp Dis Allergy, Shenzhen, Guangdong, Peoples R China
[6] Southern Med Univ, Dept Orthpaed Trauma, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China
来源：
HELIYON | 2023年 / 9卷 / 02期
关键词：
KIF20A; Cancer; Expression; Regulating mechanisms; Therapeutic target; CLEAR-CELL CARCINOMA; II CLINICAL-TRIAL; FAMILY-MEMBER; 20A; COLORECTAL-CANCER; GASTRIC-CANCER; SUPERFAMILY PROTEINS; DOWN-REGULATION; POOR-PROGNOSIS; UP-REGULATION; KINESIN;
D O I：
10.1016/j.heliyon.2023.e13195
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Kinesin family member 20A (KIF20A) is a member of the kinesin family. It transports chromo-somes during mitosis, plays a key role in cell division. Recently, studies proved that KIF20A was highly expressed in cancer. High expression of KIF20A was correlated with poor overall survival (OS). In this review, we summarized all the cancer that highly expressed KIF20A, described the role of KIF20A in cancer. We also organized phase I and phase II clinical trials of KIF20A peptides vaccine. All results indicated that KIF20A was a promising therapeutic target for multiple cancer.
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页数：16
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