Straightforward Synthesis of Trifluoromethylated Arenes via Copper-Mediated Trifluoromethylation of Diaryliodonium Salts with Fluoroform

被引：2

作者：

Zhang, Jida ^{[1
]}

Feng, Xiaomei ^{[1
]}

Guo, Taiyang ^{[1
]}

Han, Xuliang ^{[1
]}

Liu, Haodong ^{[1
]}

Li, Xiangye ^{[1
]}

Wang, Xin ^{[2
]}

Li, Hansheng ^{[2
]}

Li, Xinjin ^{[1
]}

机构：

[1] Shandong Univ Technol, Coll Chem & Chem Engn, 266 West Xincun Rd, Zibo 255000, Peoples R China

[2] State Key Lab Fluorinated Funct Membrane Mat, Dongyue Fluorosilicone Technol Grp, Zibo 256400, Peoples R China

来源：

CHEMISTRYSELECT | 2023年 / 8卷 / 14期

基金：

中国国家自然科学基金;

关键词：

trifluoromethyl; copper; diaryliodonium salts; arenes; fluoroform; NUCLEOPHILIC TRIFLUOROMETHYLATION; EFFICIENT PRECURSOR; CARBONYL-COMPOUNDS; CUCF3; REAGENTS; 1,1-DIFLUOROETHYLATION; DIFLUOROCARBENE; CHEMISTRY; HALIDES; ALKYNES;

D O I：

10.1002/slct.202301062

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild and efficient copper-mediated trifluoromethylation of diaryliodonium salts with readily available fluoroform has been developed. The reaction exhibits excellent functional group tolerance, affording trifluoromethylated arenes in good yields. This approach provides a straightforward incorporation of CF3 group into complex molecules for drug discovery.

引用

页数：4

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