Retinal peripapillary microvasculature in indirect traumatic optic neuropathy predicted prognosis of endoscopic trans-ethmosphenoid optic canal decompression

被引:2
|
作者
Ye, Jie
Zhu, Hui
Yan, Wentao
Tu, Yunhai [1 ,2 ]
Hu, Xiaozhou
Wu, Wencan [1 ,2 ]
机构
[1] Wenzhou Med Univ, Sch Ophthalmol, 270 Xueyuan Rd, Wenzhou 325027, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Optometry & Eye Hosp, 270 Xueyuan Rd, Wenzhou 325027, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
best-corrected visual acuity; endoscopic trans-ethmosphenoid optic canal decompression; indirect traumatic optic neuropathy; optical coherence tomography angiography; prognosis; retinal peripapillary microvasculature; COHERENCE TOMOGRAPHY ANGIOGRAPHY; BLOOD-FLOW DISTURBANCES; NERVE-FIBER LAYER; AXONAL LOSS; GLAUCOMA;
D O I
10.1111/aos.15243
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purposes The purpose of this study is to quantify the alteration of retinal peripapillary microvasculature and structure in unilateral indirect traumatic optic neuropathy (ITON) and figure out predicted factors of visual improvement for ITON patients with endoscopic trans-ethmosphenoid optic canal decompression (ETOCD) after one month. Methods Twenty healthy controls and 72 unilateral ITON patients were included. Optical coherence tomography angiography was used to analyse radial peripapillary capillary (RPC) density, peripapillary retinal nerve fibre layer (pRNFL) thickness, superficial retinal capillary plexus (SRCP) and deep retinal capillary plexus (DRCP) density. Associations between preoperative parameters and postoperative best-corrected visual acuity (BCVA) were determined. The receiver operating characteristic (ROC) curves were used to figure out predicted factors of visual improvement for ITON after ETOCD one month. Results In ITON eyes, the preoperative global RPC density, pRNFL thickness and SRCP density were reduced compared with unaffected eyes (p <= 0.001). Multivariate linear regression showed that preoperative global RPC density (Standardized beta = -0.273), SRCP density (Standardized beta = -0.183), DRCP density (Standardized beta = -0.098) and preoperative BCVA (Standardized beta = 0.795) were associated with the postoperative BCVA (All p < 0.001). The area under the curve (AUC) of preoperative global RPC density to predict visual improvement after ETOCD was 0.816, while the AUCs of preoperative BCVA, global pRNFL thickness, SRCP and DRCP density were 0.575, 0.756, 0.516 and 0.615, respectively. Conclusions The alteration of peripapillary area, especially the reduced RPC density, occurred in ITON eyes. The preoperative RPC density was associated with postoperative BCVA and was shown to be highly predictive for visual improvement after ETOCD one month.
引用
收藏
页码:E226 / E235
页数:10
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