Simple Ether-Directed Enantioselective C(sp3) H Borylation of Cyclopropanes Enabled by Iridium Catalysis

被引：12
|
作者：
Xie, Tian [1 ,2 ]
Chen, Lili [2 ]
Shen, Zhenlu [1 ]
Xu, Senmiao [2 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China
[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 14期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Asymmetric Catalysis; C-H Borylation; Chiral Bidentate Boryl Ligand; Cyclopropane; Synthetic Method; SIMMONS-SMITH REACTION; ALLYLIC ALCOHOLS; FUNCTIONALIZATION; SILYLATION; ACTIVATION; ACCESS;
D O I：
10.1002/anie.202300199
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reported here is an efficient and simple ether-directed iridium-catalyzed enantioselective C(sp(3)) H borylation of cyclopropanes. Various functional groups were well-tolerated, affording a vast array of chiral cyclopropanes with high enantioselectivities. We also demonstrated that the turnover numbers of the current reaction could be up to 335.
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页数：5
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