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Novel Biomarker Evaluation in Peri-Implant Crevicular Fluid as Disease Indicators for Peri-Implant Health
被引:0
|作者:
Alsahhaf, Abdulaziz
[1
]
AlHamdan, Eman M.
[1
]
Vohra, Fahim
[1
]
Abduljabbar, Tariq
[1
]
Chaudhry, Ziaullah
[2
]
Kuyunov, Isaac
[3
]
机构:
[1] King Saud Univ Riyadh, Coll Dent, Dept Prosthet Dent Sci, Riyadh 60169, Saudi Arabia
[2] Dow Univ Hlth Sci, Dr Ishrat Ul Ebad Khan Inst Oral Hlth Sci, Prosthodont Dept, Karachi 74200, Pakistan
[3] Univ Rochester, Prosthodont, Rochester, NY 14618 USA
关键词:
Biomarker;
Inflammatory Parameters;
Peri-Implant Mucositis;
Peri-Implantitis;
Peri-Implant Crevicular Fluid;
DIAGNOSIS;
CYTOKINE;
RANKL;
D O I:
10.1166/jbt.2023.3293
中图分类号:
Q813 [细胞工程];
学科分类号:
摘要:
Objective: To assess various inflammatory biomarkers CCL-20, BAF, RANK-L, IL-23, and osteoprotegerin from PICF along with clinical parameters in participants with peri-implant mucositis and peri-implantitis. Material and Methods: Participants were gathered i.e., 30 with periimplantitis, 32 with peri-implant mucositis, and 32 healthy. Peri-implant parameters PIPD, BoP, and PIPI were measured in all participants. PICF samples were collected to assess the level of biomarkers CCL-20; BAF; IL-23; RANK-L, and OPG. For periodontal parameters, ranges and means were measured. Kruskal Wallis test was used for comparison between groups. For categorical data sets, the Pearson Chi-Square test was applied. The Bonferroni test was used for multiple comparisons. Results: Peri-implant parameter BoP in peri-implant mucositis and peri-implantitis was significantly higher compared to controls (p < 0.05). PIPD with healthy peri-implant conditions was, significantly less compared to peri-implantitis, and peri-implant mucositis (p<0.05). PIPI demonstrated no significant difference throughout different peri-implant conditions. CCL-20 ng/mL in patients with peri-implant mucositis was found to be significantly higher (p < 0.05). BAF levels in peri-implantitis and peri-implant mucositis were comparable. The concentration of IL-23 ng/mL was found to be significantly lower in healthy controls (p < 0.05). Conclusion: Inflammatory biomarkers showed high levels of PICF in peri-implant disease patients compared to healthy controls. Individuals with peri-implant conditions experience the poor peri-implant probing depth and bleeding on probing.
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页码:714 / 720
页数:7
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