Significantly Longer Shedding of Norovirus Compared to Rotavirus and Adenovirus in Children with Acute Gastroenteritis

被引:3
|
作者
Qiu, Yuanyuan [1 ]
Freedman, Stephen B. [2 ,3 ]
Williamson-Urquhart, Sarah [4 ]
Farion, Ken J. [5 ,6 ]
Gouin, Serge [7 ]
Poonai, Naveen [8 ,9 ,10 ]
Schuh, Suzanne [11 ]
Finkelstein, Yaron [12 ,13 ]
Xie, Jianling [14 ]
Lee, Bonita E. [15 ]
Chui, Linda [1 ]
Pang, Xiaoli [1 ,16 ]
机构
[1] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB T6G 2R3, Canada
[2] Univ Calgary, Cumming Sch Med, Dept Pediat, Sect Pediat Emergency Med & Gastroenterol, Calgary, AB T3B 6A8, Canada
[3] Univ Calgary, Dept Emergency Med, Sect Pediat Emergency Med & Gastroenterol, Cumming Sch Med, Calgary, AB T3B 6A8, Canada
[4] Univ Calgary, Alberta Childrens Hosp, Paediat Emergency Res Team, Calgary, AB T3B 6A8, Canada
[5] Univ Ottawa, Dept Pediat, Ottawa, ON K1H 8L1, Canada
[6] Univ Ottawa, Dept Emergency Med, Ottawa, ON K1H 8L1, Canada
[7] Univ Montreal, Ctr Hosp Univ Ste Justine, Dept Pediat, Div Paediat Emergency Med, Montreal, PQ H3T 1C5, Canada
[8] Schulich Sch Med & Dent, Dept Internal Med, London, ON N6A 5W9, Canada
[9] Schulich Sch Med & Dent, Dept Epidemiol, London, ON N6A 5W9, Canada
[10] Schulich Sch Med & Dent, Dept Biostat, London, ON N6A 5W9, Canada
[11] Univ Toronto, Hosp Sick Children, Div Paediat Emergency Med, Toronto, ON M5G 1X8, Canada
[12] Univ Toronto, Div Emergency Med, Res Inst, Hosp Sick Children, Toronto, ON M5G 1X8, Canada
[13] Univ Toronto, Hosp Sick Children, Res Inst, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada
[14] Univ Calgary, Cumming Sch Med, Dept Pediat, Calgary, AB T3B 6A8, Canada
[15] Univ Alberta, Stollery Childrens Hosp, Dept Pediat, Fac Med & Dent,Women & Childrens Hlth Res Inst, Edmonton, AB T6G 2R3, Canada
[16] Publ Hlth Lab, Alberta Precis Lab, Edmonton, AB T6G 2J2, Canada
来源
VIRUSES-BASEL | 2023年 / 15卷 / 07期
基金
加拿大健康研究院;
关键词
acute gastroenteritis; norovirus; rotavirus; adenovirus; viral load; fecal shedding; children; ENTERIC VIRUSES; INFANTS; WORLD; AGE;
D O I
10.3390/v15071541
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Worldwide, acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children under 5 years of age. Viruses, including norovirus, rotavirus, and enteric adenovirus, are the leading causes of pediatric AGE. In this prospective cohort study, we investigated the viral load and duration of shedding of norovirus, rotavirus, and adenovirus in stool samples collected from 173 children (median age: 15 months) with AGE who presented to emergency departments (EDs) across Canada on Day 0 (day of enrollment), and 5 and 28 days after enrollment. Quantitative RT-qPCR was performed to assess the viral load. On Day 0, norovirus viral load was significantly lower compared to that of rotavirus and adenovirus (p < 0.001). However, on Days 5 and 28, the viral load of norovirus was higher than that of adenovirus and rotavirus (p < 0.05). On Day 28, norovirus was detected in 70% (35/50) of children who submitted stool specimens, while rotavirus and adenovirus were detected in 52.4% (11/24) and 13.6% (3/22) of children (p < 0.001), respectively. Overall, in stool samples of children with AGE who presented to EDs, rotavirus and adenovirus had higher viral loads at presentation compared to norovirus; however, norovirus was shed in stool for the longest duration.
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页数:10
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