Neoadjuvant Approaches to Non-Melanoma Skin Cancer

Simple Summary Non-melanomatous skin cancer (NMSC) is the most incident malignancy worldwide, and management can be difficult in the locally advanced setting. Here, we examine the literature on the use of neoadjuvant systemic therapy prior to surgical excision of NMSC.Abstract Surgery and external-beam radiation therapy are the primary treatment modalities for locally advanced NMSC, but they can lead to impairment of function and disfigurement in sensitive areas such as the head and neck. With the advent of targeted systemic therapies and immunotherapy, physicians have explored the ability to offer neoadjuvant therapy for NMSC in order to reduce surgically induced morbidity. Provided herein is a guide to current applications of neoadjuvant systemic therapies for NMSC and future directions.