Safety and clinical activity of oleclumab (O) ± durvalumab (D) plus chemotherapy (CT) in patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC): A phase 1b/2 randomized study

被引:0
|
作者
Coveler, Andrew L.
Reilley, Matthew
Zalupski, Mark
Macarulla, Teresa
Fountzilas, Christos
Castanon Alvarez, Eduardo
Nagrial, Adnan
Volodymyrivna Uboha, Nataliya
Frentzas, Sophia
Overman, Michael J.
Noonan, Anne M.
Messersmith, Wells A.
Pavlakis, Nick
Mettu, Niharika B.
Smith, Paul
Murtomaki, Elina
Bragulat, Veronique
Cooper, Zachary A.
Kumar, Rakesh
Spigel, David
机构
[1] Fred Hutchinson Canc Ctr, Seattle, WA USA
[2] Univ Virginia, Ctr Comprehens Canc, Charlottesville, VA USA
[3] Univ Michigan Hlth Syst, Ann Arbor, MI USA
[4] Hosp Univ Vall DHebron, Barcelona, Spain
[5] Roswell Pk Canc Inst, Buffalo, NY USA
[6] Clin Univ Navarra, Madrid, Spain
[7] Blacktown Hosp, Sydney, NSW, Australia
[8] Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA
[9] Monash Hlth Monash Med Ctr, Clayton, Vic, Australia
[10] Univ Texas MD Anderson Canc Ctr, Houston, TX USA
[11] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH USA
[12] Univ Colorado, Denver, CO USA
[13] Royal North Shore Hosp, Northern Sydney Canc Ctr, Sydney, NSW, Australia
[14] Duke Univ, Med Ctr, Durham, NC USA
[15] AstraZeneca, Cambridge, England
[16] AstraZeneca, Gaithersburg, MD USA
[17] Sarah Cannon Res Inst, Nashville, TN USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Phase 1 study of anti-immunoglobulin-like transcript 3 (ILT3) monoclonal antibody MK-0482+pembrolizumab plus gemcitabine plus nab-paclitaxel (Gem/Nab-P) in patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC).
    Golan, Talia
    Cohen, Jonathan
    Voskoboynik, Mark
    Gutierrez, Martin
    Park, John J.
    Valente, Monica
    Renouf, Daniel John
    Liu, Qi
    Edmondson, Mackenzie
    Myer, Nicole
    Kapadia, Kishan J.
    Chen, Mei
    Victoria, Ivan
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [42] Real life triplet FIr/FOx chemotherapy in first line metastatic pancreatic ductal adenocarcinoma: Recommended schedule for expected activity and safety and phase II study
    Bruera, G.
    Massacese, S.
    Manetta, R.
    Giordano, A.
    Carducci, S.
    Ciacco, E.
    Ricevuto, E.
    ANNALS OF ONCOLOGY, 2018, 29 : 43 - 43
  • [43] Safety and preliminary activity of naptumomab estafenatox (NAP) and durvalumab in patients with advanced or metastatic solid tumors: interim results from a phase 1b trial
    Geva, Ravit
    Stemmer, Salomon
    Perets, Ruth
    Maurice-Dror, Corinne
    Ben-Ami, Eitan
    Raphael, Ari
    Kumar, Sanjeev
    Lorber, Ilana
    Kedem, Tal Hetzroni
    Fields, Scott Z.
    Rozencweig, Marcel
    Golan, Talia
    CANCER RESEARCH, 2023, 83 (08)
  • [44] ARC-8: Phase I/Ib study to evaluate safety and tolerability of AB680+chemotherapy plus zimberelimab (AB122) in patients with treatment-naive metastatic pancreatic adenocarcinoma (mPDAC).
    Manji, Gulam Abbas
    Wainberg, Zev A.
    Krishnan, Kartik
    Giafis, Nick
    Udyavar, Akshata
    Quah, Cheng Seok
    Scott, Jennifer
    Berry, Wade
    DiRenzo, Daniel
    Gerrick, Kimberline
    Jin Lixia
    Bendell, Johanna C.
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (03)
  • [45] A Phase I Study of Gemcitabine/Nab-Paclitaxel/S-1 Chemotherapy in Patients With Locally Advanced or Metastatic Pancreatic Ductal Adenocarcinoma
    Chang, Chen
    Li, Xiaofen
    Cheng, Ke
    Cai, Zhaolun
    Xiong, Junjie
    Lv, Wanrui
    Li, Ruizhen
    Zhang, Pei
    Cao, Dan
    ONCOLOGIST, 2023, 28 (07): : E575 - E584
  • [46] CD40 agonist mitazalimab combined with mFOLFIRINOX (mFFX) in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC): Primary analysis of the OPTIMIZE-1 phase Ib/II study
    Macarulla Mercade, T.
    Borbath, I.
    Geboes, K.
    Lambert, A.
    Cassier, P.
    Prenen, H.
    Mitry, E.
    Blanc, J. F.
    Pilla, L.
    Feliu, J.
    Rodriguez, M.
    Cid, R. A. Pazo
    Gallego Jimenez, I.
    Gomez Jimenez, D.
    Smith, K. E.
    Nordbladh, K.
    Ellmark, P.
    Pico de Coana, Y.
    Ambarkhane, S. V.
    van Laethem, J-L.
    ANNALS OF ONCOLOGY, 2024, 35 : S118 - S118
  • [47] Preliminary results of a phase II study of surufatinib plus sintilimab, nab-paclitaxel and gemcitabine (AG) as first-line therapy in patients (pts) with locally advanced or metastatic pancreatic adenocarcinoma (mPDAC).
    Zhang, Dong-Sheng
    Liu, Fu-Rong
    Lu, Yun-Xin
    Bai, Bing
    Zhang, Yang
    Wang, Zhi-Qiang
    Liu, Yu
    Chen, Jian-Wen
    Wang, Feng
    Xu, Rui-Hua
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (3_SUPPL) : 659 - 659
  • [48] Liposomal irinotecan (nal-IRI) plus 5-FU/LV in patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC) progressing on gemcitabine-based treatment: Further subgroup analyses of the pivotal NAPOLI-1 study
    Chen, L-T.
    Macarulla Mercade, T.
    Lee, K-H.
    Lakatos, G.
    Wang-Gillam, A.
    Mirakhur, B.
    de Jong, F.
    ANNALS OF ONCOLOGY, 2018, 29
  • [49] Phase 1b study to assess the safety, tolerability, and clinical activity of pamiparib in combination with temozolomide in patients with locally advanced or metastatic solid tumors
    Stradella, Agostina
    Johnson, Melissa
    Goel, Sanjay
    Park, Haeseong
    Lakhani, Nehal
    Arkenau, Hendrik-Tobias
    Galsky, Matthew D.
    Calvo, Emiliano
    Baz, Vicente
    Moreno, Victor
    Saavedra, Omar
    Luen, Stephen J.
    Mu, Song
    Wan, Qiting
    Chang, Victoria
    Zhang, Wa
    Barve, Minal
    CANCER MEDICINE, 2024, 13 (13):
  • [50] A phase I study of gemcitabine/nab-paclitaxel/S-1 chemotherapy in patients with locally advanced or metastatic pancreatic ductal adenocarcinoma.
    Chang, Chen
    Li, Xiaofen
    Cheng, Ke
    Cai, Zhaolun
    Xiong, Junjie
    Lv, Wanrui
    Li, Ruizhen
    Zhang, Pei
    Cao, Dan
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16) : E16261 - E16261