Involvement of the Expression of G Protein-Coupled Receptors in Schizophrenia

被引：4

作者：

Kalinovic, Raluka ^{[1
,2
]}

Pascariu, Andrei ^{[2
]}

Vlad, Gabriela ^{[2
]}

Nitusca, Diana ^{[3
,4
]}

Salcudean, Andreea ^{[5
]}

Sirbu, Ioan Ovidiu ^{[3
,4
]}

Marian, Catalin ^{[3
,4
]}

Enatescu, Virgil Radu ^{[2
,6
]}

机构：

[1] Univ Med & Pharm Victor Babes Timisoara, Doctoral Sch, Timisoara 300041, Romania

[2] Timisoara Cty Emergency Clin Hosp, Eduard Pamfil Psychiat Clin, Timisoara 300425, Romania

[3] Univ Med & Pharm Victor Babes Timisoara, Dept Biochem, Timisoara 300041, Romania

[4] Victor Babes Univ Med & Pharm, Ctr Complex Networks Sci, Pta Eftimie Murgu 2, Timisoara 300041, Romania

[5] George Emil Palade Univ Med Pharm Sci & Technol Ta, Dept Ethics & Social Sci, Discipline Sociobiol, Targu Mures 540136, Romania

[6] Univ Med & Pharm Victor Babes Timisoara, Dept Neurosci, Discipline Psychiat, Timisoara 300041, Romania

来源：

PHARMACEUTICALS | 2024年 / 17卷 / 01期

关键词：

schizophrenia; G protein-coupled receptors; psychosis; cognitive deficit; super conserved receptor expressed in the brain; L-TRYPTOPHAN; RISK; PATHOPHYSIOLOGY; SREB2/GPR85; HYPOTHESIS; GLUTAMATE; REGIONS; GPR139; GPR85;

D O I：

10.3390/ph17010085

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The expression of GPCRs has been associated with schizophrenia, and their expression may induce morphological changes in brain regions responsible for schizophrenia and disease-specific behavioral changes. The articles included in this review were selected using keywords and databases of scientific research websites. The expressions of GPRs have different involvements in schizophrenia, some increase the risk while others provide protection, and they may also be potential targets for new treatments. Proper evaluation of these factors is essential to have a better therapeutic response with a lower rate of chronicity and thus improve the long-term prognosis.

引用

页数：11

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