The intricate role of annexin A2 in kidney: a comprehensive review

被引：2
|
作者：
Lei, Juan [1 ]
Sun, Pingping [2 ]
Sheng, Jingyi [1 ]
Wang, Hongri [1 ]
Xie, Yifan [3 ]
Song, Jiayu [1 ,4 ]
机构：
[1] Nanjing Med Univ, Dept Pediat Nephrol, Affiliated Hosp 2, Nanjing, Jiangsu, Peoples R China
[2] Capital Med Univ, Beijing Chao Yang Hosp, Dept Internal Med, Beijing, Peoples R China
[3] Nanjing Med Univ, Childrens Hosp, Dept Rheumatism & Immunol, Nanjing, Jiangsu, Peoples R China
[4] Nanjing Med Univ, Affiliated Hosp 2, Dept Pediat Nephrol, Nanjing 210003, Jiangsu, Peoples R China
来源：
RENAL FAILURE | 2023年 / 45卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Annexin A2; Ca2+-dependent; acute kidney injury; chronic kidney disease; renal cell carcinoma; nephrolithiasis; RENAL-CELL CARCINOMA; PROTEOMIC ANALYSIS; DIABETIC-NEPHROPATHY; BINDING PROTEINS; EXPRESSION; MEMBRANE; CALCIUM; SYSTEM; HETEROTETRAMER; IDENTIFICATION;
D O I：
10.1080/0886022X.2023.2273427
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Annexin A2 (Anxa2) is a calcium (Ca2+)-regulated phospholipid binding protein composed of a variable N-terminus and a conserved core domain. This protein has been widely found in many tissues and fluids, including tubule cells, glomerular epithelial cells, renal vessels, and urine. In acute kidney injury, the expression level of this protein is markedly elevated in response to acute stress. Moreover, Anxa2 is a novel biomarker and potential therapeutic target with prognostic value in chronic kidney disease. In addition, Anxa2 is associated not only with clear-cell renal cell carcinoma differentiation but also the formation of calcium-related nephrolithiasis. In this review, we discuss the characteristics and functions of Anxa2 and focus on recent reports on the role of Anxa2 in the kidney, which may be useful for future research.
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页数：11
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