Decarboxylative N-Formylation of Amines with Glyoxylic Acid Promoted by H2O2

被引：1
|
作者：
Wu, Jiwei [1 ]
Zhang, Yuting [1 ]
Yang, Jingyi [1 ]
Yu, Lingxiang [1 ]
Zhang, Shaoqing [1 ]
Zhou, Jie [2 ]
Li, Zirong [1 ]
Xu, Xiaolan [3 ]
Xu, Huajian [2 ]
机构：
[1] Anhui Sci & Technol Univ, Coll Chem & Mat Engn, Fengyang 233100, Peoples R China
[2] Hefei Univ Technol, Inst Ind & Equipment Technol, Sch Chem & Chem Engn, Sch Food & Biol Engn, Hefei 230009, Peoples R China
[3] Anhui Med Univ, Sch Med Sci, Hefei 230009, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 19期
关键词：
ONE-STEP SYNTHESIS; ALPHA-KETO ACIDS; HIGHLY EFFICIENT; CARBON-DIOXIDE; ROOM-TEMPERATURE; ARYL HALIDES; TRANSAMIDATION; ISOCYANIDES; AMIDATION; ALDEHYDES;
D O I：
10.1021/acs.joc.3c01270
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel method for the synthesis of formamides through the decarboxylative N-formylation of amines with glyoxylic acid has been developed. This transformation provides an efficient protocol for the synthesis of various formamides with moderate to excellent yields, and it can accommodate a wide range of functional groups under metal free and base free conditions. In addition, the large-scale experiments and high chemoselectivity have shown great potential application of this strategy.
引用
收藏
页码：13590 / 13597
页数：8
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