The Longitudinal Kinetics of AAV5 Vector Integration Profiles in Mice

被引：0
|
作者：
Ismail, Ashrafali Mohamed [1 ]
Witt, Evan [1 ]
Bouwman, Taren [1 ]
Clark, Wyatt [1 ]
Yates, Bridget [1 ]
Franco, Matteo [2 ,3 ]
Fong, Sylvia [1 ]
机构：
[1] BioMarin Pharmaceut Inc, Novato, CA USA
[2] ProtaGene CGT GmbH, Heidelberg, Germany
[3] ProtaGene US Inc, Burlington, MA USA
来源：
MOLECULAR THERAPY | 2023年 / 31卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
65
引用
收藏
页码：35 / 35
页数：1
相关论文
共 50 条
  • [41] Vector genome loss and epigenetic modifications mediate decline in transgene expression of AAV5 vectors produced in mammalian and insect cells
    Handyside, Britta
    Ismail, Ashrafali Mohamed
    Zhang, Lening
    Yates, Bridget
    Xie, Lin
    Sihn, Choong-Ryoul
    Murphy, Ryan
    Bouwman, Taren
    Kim, Chan Kyu
    De Angelis, Rolando
    Karim, Omair A.
    McIntosh, Nicole L.
    Doss, Michael Xavier
    Shroff, Shilpa
    Pungor, Erno
    Bhat, Vikas S.
    Bullens, Sherry
    Bunting, Stuart
    Fong, Sylvia
    MOLECULAR THERAPY, 2022, 30 (12) : 3570 - 3586
  • [42] Analysis of AAV5 Biodistribution and Viral Shedding in the Presence or Absence of Neutralizing Antibodies
    Salas, David
    Majowicz, Anna
    Zabaleta, Nerea
    Rodriguez-Garcia, Estefania
    Petry, Harald
    Ferreira, Valerie
    Gonzalez Aseguinolaza, Gloria
    MOLECULAR THERAPY, 2016, 24 : S125 - S125
  • [43] The Multi-Serotype Receptor AAVR Interacts with AAV2 and AAV5 via Separate Domains
    Pillay, Sirika
    Zou, Wei
    Cheng, Fang
    Davulcu, Omar
    Ganaie, Safder S.
    Puschnik, Andreas
    Deng, Xuefeng
    Meyer, Nancy L.
    Ishikawa, Yoshihiro
    Yan, Ziying
    Engelhardt, John F.
    Brown, Kevin E.
    Chapman, Michael S.
    Carette, Jan E.
    Qiu, Jianming
    MOLECULAR THERAPY, 2017, 25 (05) : 3 - 3
  • [44] Global Seroprevalence of Pre-existing Immunity Against AAV5 and Other AAV Serotypes in People with Hemophilia A
    Klamroth, Robert
    Hayes, Gregory
    Andreeva, Tatiana
    Gregg, Keith
    Suzuki, Takashi
    Mitha, Ismail Haroon
    Hardesty, Brandon
    Shima, Midori
    Pollock, Toni
    Slev, Patricia
    Oldenburg, Johannes
    Ozelo, Margareth C.
    Stieltjes, Natalie
    Castet, Sabine-Marie
    Mahlangu, Johnny
    Peyvandi, Flora
    Kazmi, Rashid
    Schved, Jean-Francois
    Leavitt, Andrew D.
    Callaghan, Michael
    Pan-Petesch, Brigitte
    Quon, Doris, V
    Andrews, Jayson
    Trinh, Alex
    Li, Mingjin
    Wong, Wing Yen
    HUMAN GENE THERAPY, 2022, 33 (7-8) : 432 - 441
  • [45] Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5
    Walters, RW
    Pilewski, JM
    Chiorini, JA
    Zabner, J
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (26) : 23709 - 23713
  • [46] Prophylactic Prednisolone Promotes AAV5 Hepatocyte Transduction Through the Novel Mechanism of AAV5 Coreceptor Platelet-Derived Growth Factor Receptor Alpha Upregulation and Innate Immune Suppression
    Handyside, Britta
    Zhang, Lening
    Yates, Bridget
    Xie, Lin
    Ismail, Ashrafali Mohamed
    Murphy, Ryan
    Baridon, Brian
    Su, Cheng
    Bouwman, Taren
    Mangini, Linley
    Tahquechi, Jorden
    Salcido, Sandra
    Minto, Wesley C.
    Keenan, William T.
    Ntai, Ioanna
    Sihn, Choong-Ryoul
    Bullens, Sherry
    Bunting, Stuart
    Fong, Sylvia
    HUMAN GENE THERAPY, 2024, 35 (1-2) : 36 - 47
  • [47] Comparable efficiency of photoreceptor transduction by AAV2tYF, AAV5 and AAV8 in non-human primates
    Shearman, M. S.
    Song, C. J.
    Ye, G.
    Timmers, A. M.
    Newmark, J.
    HUMAN GENE THERAPY, 2018, 29 (12) : A153 - A153
  • [48] Genetic Modification of the AAV5 Capsid Resulting in De-Targeted Liver and Enhanced Vector Delivery to Lung Following Intravenous Administration
    Stiles, Katie M.
    Frenk, Esther Z.
    Kaminsky, Stephen M.
    Crystal, Ronald G.
    MOLECULAR THERAPY, 2018, 26 (05) : 318 - 318
  • [49] Self-complementary AAV5 vector facilitates quicker transgene expression in photoreceptor and retinal pigment epithelial cells of normal mouse
    Kong, Fansheng
    Li, Wensheng
    Li, Xia
    Zheng, Qinxiang
    Dai, Xufeng
    Zhou, Xiangtian
    Boye, Sanford L.
    Hauswirth, William W.
    Qu, Jia
    Pang, Ji-Jing
    EXPERIMENTAL EYE RESEARCH, 2010, 90 (05) : 546 - 554
  • [50] Genetic Modification of the AAV5 Capsid with Lysine Residues Results in a Lung-Tropic Liver-Detargeted Gene Transfer Vector
    Stiles, Katie M.
    Frenk, Esther Z.
    Kaminsky, Stephen M.
    Crystal, Ronald G.
    HUMAN GENE THERAPY, 2022, 33 (3-4) : 148 - 154
12345