Effect of Paxlovid on Tacrolimus Concentration in Perioperative Kidney Transplant Patients Infected With COVID-19: A Case Report

被引：1

作者：

Liu, Yuewen ^{[1
]}

Liu, Yanfang ^{[2
]}

Cai, Chaohong ^{[2
]}

Hui, Fuhai ^{[3
]}

Zhang, Yan ^{[4
]}

Wang, Boqian ^{[1
]}

Wang, Xueyi ^{[1
]}

Zhang, Yijian ^{[1
]}

Song, Xing ^{[1
]}

He, Long ^{[1
]}

Yang, Hongwei ^{[1
]}

机构：

[1] Gen Hosp Northern Theater Command, Organ Transplantat Ctr, 5 Guangrong St, Shenyang 110010, Liaoning, Peoples R China

[2] Gen Hosp Northern Theater Command, Dept Clin Trial Ctr, Shenyang, Peoples R China

[3] Shenyang Pharmaceut Univ, Dept Clin Pharm, Shenyang, Peoples R China

[4] Gen Hosp Northern Theater Command, Dept Pharm, Shenyang, Peoples R China

来源：

TRANSPLANTATION PROCEEDINGS | 2023年 / 55卷 / 08期

关键词：

D O I：

10.1016/j.transproceed.2023.07.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Paxlovid, as a new drug, received emergency approval for the treatment of COVID-19 in China; there is very little experience with kidney transplantation patients taking tacrolimus with perioperative COVID-19 infection. We discontinued tacrolimus on the day of using Paxlovid, and we chose to frequently monitor the concentration of tacrolimus and creatinine early in the course of treatment by enzyme multiplied immunoassay technique (EMIT) and liquid chromatographymass spectrometry (LC-MS/MS). The results show varying degrees of elevation of creatinine levels in 3 patients, and EMIT may overestimate the true concentration of tacrolimus metabolites compared with LC-MS/MS. All the data comply with the Helsinki Congress and the Declaration of Istanbul.

引用

页码：1822 / 1825

页数：4

共 50 条

[41] A CASE OF SUSPECTED COVID-19 REACTIVATION IN A KIDNEY TRANSPLANT RECIPIENT
Primi, Blake
Basak, Jacob
CRITICAL CARE MEDICINE, 2022, 50 (01) : 80 - 80
[42] COVID-19 in kidney transplant recipients
Gandolfini, Ilaria
Delsante, Marco
Fiaccadori, Enrico
Zaza, Gianluigi
Manenti, Lucio
Degli Antoni, Anna
Peruzzi, Licia
Riella, Leonardo V.
Cravedi, Paolo
Maggiore, Umberto
AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 (07) : 1941 - 1943
[43] COVID-19 in a Kidney Transplant Patient
Wang, Junpeng
Li, Xin
Cao, Guanghui
Wu, Xiaoqiang
Wang, Zhiwei
Yan, Tianzhong
EUROPEAN UROLOGY, 2020, 77 (06) : 769 - 770
[44] Kidney transplant after a COVID-19
Pascual, Julio
NEFROLOGIA, 2021, 41 (02): : 91 - 94
[45] COVID-19 and kidney transplant recipients
Abolghasemi, Sara
Mardani, Masoud
Sali, Shahnaz
Honarvar, Negin
Baziboroun, Mana
TRANSPLANT INFECTIOUS DISEASE, 2020, 22 (06)
[46] Kidney transplant recipients infected by COVID-19: Review of the initial published experience
Moris, Dimitrios
Kesseli, Samuel J.
Barbas, Andrew S.
TRANSPLANT INFECTIOUS DISEASE, 2020, 22 (06)
[47] COVID-19 and acute kidney injury; a case report
Ghobadi, Hassan
Kalan, Mohammad Ebrahimi
Mohammad-Shahi, Jafar
Ben Taleb, Ziyad
Kalan, Abbas Ebrahimi
Fazlzadeh, Mehdi
JOURNAL OF RENAL INJURY PREVENTION, 2020, 9 (03):
[48] Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation?
Guillen, Elena
Pineiro, Gaston J.
Revuelta, Ignacio
Rodriguez, Diana
Bodro, Marta
Moreno, Asuncion
Campistol, Josep M.
Diekmann, Fritz
Ventura-Aguiar, Pedro
AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 (07) : 1875 - 1878
[49] Withdrawing mycophenolate mofetil in treating a young kidney transplant recipient with COVID-19 A case report
Chen, Dong
Yang, Bo
Zhang, Yan
Chen, Liang
Wei, Lai
Zhang, Weijie
Wang, Xinqiang
Tong, Xiaolin
Chen, Zhishui
MEDICINE, 2020, 99 (24) : E20481
[50] COVID-19 infection in a kidney transplant recipient——special emphasis on pharmacokinetic interactions:A case report
Ebru Gok Oguz
Kadir Gokhan Atilgan
Sanem Guler Cimen
Hatice Sahin
Tamer Selen
Fatma Ayerden Ebinc
Sertac Cimen
Mehmet Deniz Ayli
World Journal of Transplantation, 2020, (11) : 365 - 371

← 1 2 3 4 5 →