Mitochondrial transfer in hematological malignancies

被引：9
|
作者：
Guo, Xiaodong [1 ]
Can, Can [1 ]
Liu, Wancheng [1 ]
Wei, Yihong [1 ]
Yang, Xinyu [1 ]
Liu, Jinting [1 ]
Jia, Hexiao [1 ]
Jia, Wenbo [1 ]
Wu, Hanyang [1 ]
Ma, Daoxin [1 ]
机构：
[1] Shandong Univ, Qilu Hosp, Dept Hematol, Jinan 250012, Shandong, Peoples R China
来源：
BIOMARKER RESEARCH | 2023年 / 11卷 / 01期
关键词：
Mitochondrial transfer; Tunneling nanotubes; Extracellular vesicles; Extracellular mitochondria; Hematological malignancies; MESENCHYMAL STEM-CELLS; MARROW STROMAL CELLS; CHRONIC MYELOGENOUS LEUKEMIA; TUNNELING NANOTUBES; EXTRACELLULAR VESICLES; INTERCELLULAR COMMUNICATION; MULTIPLE-MYELOMA; TNT FORMATION; CANCER-CELLS; IN-VITRO;
D O I：
10.1186/s40364-023-00529-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mitochondria are energy-generated organelles and take an important part in biological metabolism. Mitochondria could be transferred between cells, which serves as a new intercellular communication. Mitochondrial transfer improves mitochondrial defects, restores the biological functions of recipient cells, and maintains the high metabolic requirements of tumor cells as well as drug resistance. In recent years, it has been reported mitochondrial transfer between cells of bone marrow microenvironment and hematological malignant cells play a critical role in the disease progression and resistance during chemotherapy. In this review, we discuss the patterns and mechanisms on mitochondrial transfer and their engagement in different pathophysiological contexts and outline the latest knowledge on intercellular transport of mitochondria in hematological malignancies. Besides, we briefly outline the drug resistance mechanisms caused by mitochondrial transfer in cells during chemotherapy. Our review demonstrates a theoretical basis for mitochondrial transfer as a prospective therapeutic target to increase the treatment efficiency in hematological malignancies and improve the prognosis of patients.
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收藏
页数：16
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