Clinical Ocular Exposure Extrapolation Using PBPK Modeling and Simulation: Besifloxacin Suspension Case Study

被引:0
|
作者
Le Merdy, Maxime [1 ]
AlQaraghuli, Farah [1 ]
Lukacova, Viera [1 ]
机构
[1] Simulations Plus Inc, Lancaster, CA USA
关键词
D O I
暂无
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [21] PBPK MODELING AND SIMULATION OF MORPHINE IN VIRTUAL NEONATES GENERATED USING ACTUAL PATIENT INFORMATION
    Emoto, Chie
    Hahn, David
    Euteneuer, Joshua
    Mizuno, Tomoyuki
    Vinks, Alexander
    Fukuda, Tsuyoshi
    DRUG METABOLISM AND PHARMACOKINETICS, 2020, 35 (01) : S86 - S87
  • [22] The use of PBPK modeling across the pediatric age range using propofol as a case
    Robin Michelet
    Jan Van Bocxlaer
    Karel Allegaert
    An Vermeulen
    Journal of Pharmacokinetics and Pharmacodynamics, 2018, 45 : 765 - 785
  • [23] The use of PBPK modeling across the pediatric age range using propofol as a case
    Michelet, Robin
    Van Bocxlaer, Jan
    Allegaert, Karel
    Vermeulen, An
    JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2018, 45 (06) : 765 - 785
  • [24] Assessment of the Long-Term Exposure to Lead in Four European Countries Using PBPK Modeling
    Sy, Moustapha
    Eleftheriadou, Dimitra
    Jung, Christian
    Lindtner, Oliver
    Karakitsios, Spyros
    Sarigiannis, Dimosthenis
    Weber, Till
    Kolossa-Gehring, Marike
    Greiner, Matthias
    EXPOSURE AND HEALTH, 2024, 16 (01) : 21 - 39
  • [25] Assessment of the Long-Term Exposure to Lead in Four European Countries Using PBPK Modeling
    Moustapha Sy
    Dimitra Eleftheriadou
    Christian Jung
    Oliver Lindtner
    Spyros Karakitsios
    Dimosthenis Sarigiannis
    Till Weber
    Marike Kolossa-Gehring
    Matthias Greiner
    Exposure and Health, 2024, 16 : 21 - 39
  • [26] A simulation study of extrapolation uncertainty in exposure assessment - Use of pilot study results for site investigation
    Goodrum, Philip E.
    Mendelsohn, Emma S.
    Roberts, Stephen M.
    Stuchal, Leah D.
    JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2024, 356
  • [27] In Silico Pharmacokinetic Study of Vancomycin Using PBPK Modeling and Therapeutic Drug Monitoring
    Ferreira, Abigail
    Martins, Helena
    Oliveira, Jose C.
    Lapa, Rui
    Vale, Nuno
    CURRENT DRUG METABOLISM, 2021, 22 (02) : 150 - 162
  • [28] A Workflow Example of PBPK Modeling to Support Pediatric Research and Development: Case Study with Lorazepam
    A. R. Maharaj
    J. S. Barrett
    A. N. Edginton
    The AAPS Journal, 2013, 15 : 455 - 464
  • [29] A Workflow Example of PBPK Modeling to Support Pediatric Research and Development: Case Study with Lorazepam
    Maharaj, A. R.
    Barrett, J. S.
    Edginton, A. N.
    AAPS JOURNAL, 2013, 15 (02): : 455 - 464
  • [30] Addressing complexity using distributed simulation: A case study in spaceport modeling
    Park, J
    Moraga, R
    Rabelo, L
    Dawson, J
    Marin, M
    Sepulveda, J
    PROCEEDINGS OF THE 2005 WINTER SIMULATION CONFERENCE, VOLS 1-4, 2005, : 1804 - 1812