Control of a complex multistep process for the production of mesalazine

被引：6

作者：

Castillo, Ismael ^{[1
]}

Rehrl, Jakob ^{[2
]}

Sagmeister, Peter ^{[2
,3
]}

Lebl, Rene ^{[2
,3
]}

Kruisz, Julia ^{[2
]}

Celikovic, Selma ^{[1
]}

Sipek, Martin ^{[4
]}

Kirschneck, Dirk ^{[5
]}

Horn, Martin ^{[1
]}

Sacher, Stephan ^{[2
]}

Cantillo, David ^{[2
,3
]}

Williams, Jason D. ^{[2
,3
]}

Khinast, Johannes G. ^{[2
,6
]}

Kappe, Oliver ^{[2
,3
]}

机构：

[1] Graz Univ Technol, Inst Automat & Control, Inffeldgasse 21b, A-8010 Graz, Austria

[2] Res Ctr Pharmaceut Engn GmbH, Inffeldgasse 13-2, A-8010 Graz, Austria

[3] Karl Franzens Univ Graz, Inst Chem, Heinrichstr, A-8010 Graz, Austria

[4] Evon GmbH, Wollsdorf 154, A-8181 St Ruprecht, Austria

[5] Microinnova Engn GmbH, Europapk 1, A-8412 Allerheiligen, Austria

[6] Graz Univ Technol, Inst Proc & Particle Engn, Inffeldgasse 13-3, A-8010 Graz, Austria

来源：

JOURNAL OF PROCESS CONTROL | 2023年 / 122卷

关键词：

Multi-step continuous flow process; Synthesis of active pharmaceutical; ingredient; Data driven models; LoLiMoT identification; Non-linear model predictive control; SYSTEMS; STATE;

D O I：

10.1016/j.jprocont.2022.12.009

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

This paper presents the application of Data Driven Modelling (DDM) and Non-Linear Model Predictive Control (NMPC) for the control implementation of a continuous reactor for the production of the Active Pharmaceutical Ingredient (API), Mesalazine. The contribution of this work is to present the overall control architecture, the step-by-step controller design based on DDM, i.e. Neuro-Fuzzy/Local Linear Model Tree Models (LoLiMoT) and NMPC. We demonstrate the advantages of DDM and NMPC, in the presence of non-linear, distributed parameter, multi-variable systems as a suitable, powerful and practical way to approach complex process control challenges. Compared to conventional concepts, the inherent optimization structure of NMPC allows to obtain the desired behaviour of the multi-variable non-linear plant considering the physical constraints of operation regions. The control concept has been implemented in the real system on one central computer, XamControl (Evon),1 with all measurement devices and actuators centrally interconnected.(c) 2022 Elsevier Ltd. All rights reserved.

引用

页码：59 / 68

页数：10

共 50 条

[31] Spectrophotometric determination of Mesalazine by formation of ion pair complex
Al-Obaidi, Muhannad Salim Miteb
Al-Samarrai, Eman Thiab
EURASIAN CHEMICAL COMMUNICATIONS, 2022, 4 (09): : 826 - 834
[32] Complex Control Method of Degreasing Process
Zoubek, Michal
Kudlacek, Jan
Chabera, Petr
Abramov, Andrey
ADVANCES IN MANUFACTURING (MANUFACTURING 2017), 2018, : 575 - 585
[33] The Application of Process Quality Control Tools in the Production Process
Ma, L. X.
Dong, S. C.
Wang, J.
ADVANCES IN MATERIALS MANUFACTURING SCIENCE AND TECHNOLOGY XIII, VOL 1: ADVANCED MANUFACTURING TECHNOLOGY AND EQUIPMENT, AND MANUFACTURING SYSTEMS AND AUTOMATION, 2009, 626-627 : 741 - 746
[34] Constructional bamboo plywood process control and production process
Feng, Mingzhi
Zhao, Ruilong
Lv, Na
Zhang, Shuangbao
FRONTIERS OF MECHANICAL ENGINEERING AND MATERIALS ENGINEERING, PTS 1 AND 2, 2012, 184-185 : 728 - 731
[35] Production control as a complex dynamic object
Groumpos, P
Ilyasov, B
Ismagilova, L
Valeeva, R
LARGE SCALE SYSTEMS: THEORY AND APPLICATIONS 1998 (LSS'98), VOL 1, 1999, : 517 - 520
[36] Production control of complex material flows
Seitz M.
Mütze A.
Nyhuis P.
ZWF Zeitschrift fuer Wirtschaftlichen Fabrikbetrieb, 2019, 114 (12): : 828 - 834
[37] AGING AS A MULTISTEP PROCESS CHARACTERIZED BY A LOWERING OF ENTROPY PRODUCTION LEADING THE CELL TO A SEQUENCE OF DEFINED STAGES
TOUSSAINT, O
RAES, M
REMACLE, J
MECHANISMS OF AGEING AND DEVELOPMENT, 1991, 61 (01) : 45 - 64
[38] Research on equilibrium production in complex manufacturing process
Yan, Zhuang
PROCEEDINGS OF THE 2014 INTERNATIONAL CONFERENCE ON MECHATRONICS, CONTROL AND ELECTRONIC ENGINEERING, 2014, 113 : 854 - 857
[39] CONCENTRATION AND SPECIALIZATION OF THE PRODUCTION - PLANNED AND COMPLEX PROCESS
KOHLER, W
FLEISCH, 1979, 33 (05): : 83 - 85
[40] A COMPLEX AND NECESSARY PROCESS - EVALUATION OF THE PRODUCTION SYSTEMS
Stefanescu, Roxana
METALURGIA INTERNATIONAL, 2009, 14 : 147 - 151

← 1 2 3 4 5 →