Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology

被引:9
|
作者
Jafernik, Karolina [1 ]
Motyka, Sara [1 ,2 ]
Calina, Daniela [3 ]
Sharifi-Rad, Javad [4 ]
Szopa, Agnieszka [1 ]
机构
[1] Jagiellonian Univ, Coll Med, Chair & Dept Pharmaceut Bot, Med St 9, Krakow, Poland
[2] Jagiellonian Univ, Doctoral Sch Med & Hlth Sci, Med Coll, Lazarza 16 St, PL-31530 Krakow, Poland
[3] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova 200349, Romania
[4] Univ Azuay, Fac Med, Cuenca, Ecuador
关键词
Schisandra lignans; Bicyclol; Anticancer activity; Dibenzocyclootadiene lignans; Apoptosis; Molecular mechanisms; INDUCED LIVER-INJURY; IN-VITRO CULTURES; CELL-CYCLE ARREST; SPHENANTHERA-EXTRACT; ANTIOXIDANT ACTIVITY; CYTOTOXIC ACTIVITY; GOMISIN-B; CHINENSIS; NORTRITERPENOIDS; PROPINQUA;
D O I
10.1186/s13020-024-00879-0
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Cancer remains one of the leading causes of mortality worldwide. The search for novel and effective anticancer agents has been a significant area of research. Dibenzocyclooctadiene lignans (DBCLS), derived from the Schisandra genus plants like: S. chinensis, S. sphenanthera, S. henryi, S. rubriflora, S. grandiflora, S. propinqua, and S. glabra, have been traditionally used in various medicinal systems and are known for their myriad health benefits, including anticancer properties. This comprehensive review aimed to collate and critically analyse the recent literature on the anticancer properties of DBCLS, focusing on their mechanistic approaches against different cancer types. An exhaustive literature search was performed using databases like PubMed/MedLine, Scopus, Web of Science, Embase, TRIP database and Google Scholar from 1980 to 2023. Peer-reviewed articles that elucidated the mechanistic approach of these lignans on cancer cell lines, in vivo models and preliminary clinical studies were included. Studies were assessed for their experimental designs, cancer types studied, and the mechanistic insights provided. The studies demonstrate that the anticancer effects of DBCLS compounds are primarily driven by their ability to trigger apoptosis, arrest the cell cycle, induce oxidative stress, modulate autophagy, and disrupt essential signaling pathways, notably MAPK, PI3K/Akt, and NF-kappa B. Additionally, these lignans have been shown to amplify the impact of traditional chemotherapy treatments, suggesting their potential role as supportive adjuncts in cancer therapy. Notably, several studies also emphasise their capacity to target cancer stem cells and mitigate multi-drug resistance specifically. DBCLS from the Schisandra genus have showcased significant potential as anticancer agents. Their multi-targeted mechanistic approach makes them promising candidates for further research, potentially leading to developing of new therapeutic strategies in cancer management.
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页数:26
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