Functional-Group-Tolerant Pd-Catalyzed Carbonylative Negishi Coupling with Aryl Iodides

被引：2
|
作者：
Kalinin, Dmitrii [1 ,2 ]
Ulven, Trond [1 ,3 ]
机构：
[1] Univ Southern Denmark, Dept Phys Chem & Pharm, DK-5230 Odense, Denmark
[2] Univ Munster, Inst Pharmaceut & Med Chem, D-48149 Munster, Germany
[3] Univ Copenhagen, Dept Drug Design & Pharmacol, DK-2100 Copenhagen, Denmark
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 23期
关键词：
UNSYMMETRICAL KETONE SYNTHESIS; UNACTIVATED ALKYL BROMIDES; ORGANOZINC REAGENTS; CONVENIENT SYNTHESIS; ORGANIC HALIDES; CROSS-COUPLINGS; EMPETRUM-NIGRUM; FLUORIDE-ION; PALLADIUM; ZINC;
D O I：
10.1021/acs.joc.3c00948
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A chemoselective Pd-mediated carbonylative Negishi-type catalytic protocol for the synthesis of (hetero)-aryl ketones is reported. The protocol employs the PEPPSI-IPr precatalyst and CO gas at atmospheric pressure (balloon) to foster the carbonylative coupling between diverse C-(sp3)-hybridized organozinc reagents and a broad range of aryl iodides, including substrates carrying aldehyde, aniline, phenol, or carboxylic acid groups, and heteroaryls.
引用
收藏
页码：16633 / 16638
页数：6
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