Microwave-Assisted Synthesis of 5-Substituted 3-Amino-1,2,4-triazoles from Aminoguanidine Bicarbonate and Carboxylic Acids

被引:4
|
作者
Gumus, Mustafa Kemal [1 ]
Gorobets, Mykola Yu. [2 ]
Uludag, Nesimi [3 ]
机构
[1] Artvin Coruh Univ, Sci Technol Res & Applicat Ctr, TR-08000 Artvin, Turkiye
[2] NAS Ukraine, SSI Inst Single Crystals, 60 Nauky Ave, UA-61001 Kharkov, Ukraine
[3] Namik Kemal Univ, Fac Sci & Arts, Dept Chem, TR-59030 Tekirdag, Turkiye
关键词
aminoguanidine; 3-amino-1,2,4-triazoles; carboxylic acids; microwave-assisted synthesis; MODIFIED BIGINELLI REACTION; ONE-POT SYNTHESIS; TRIAZOLE DERIVATIVES; 1,2,4-TRIAZOLE; TAUTOMERISM; ADSORPTION; SCAFFOLD; COPPER; SALTS;
D O I
10.3390/pr12030573
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
The effect of the molar ratio between reagents, reaction time and temperature on the yield of 5-substituted 3-amino-1,2,4-triazoles obtained by the direct condensation of carboxylic acids with aminoguanidine bicarbonate under acid catalysis conditions was studied. As a result, a general green straightforward synthesis of the title compounds bearing aliphatic substituents or a phenyl ring was developed using sealed reaction vials under controlled microwave synthesis conditions that are suitable for the application of volatile starting carboxylic acids. Our straightforward synthetic method proposed in this work increases the synthetic accessibility of these widely used building blocks and therefore is able to significantly expand the structural diversity of compounds containing a triazole moiety for the needs of drug discovery.
引用
收藏
页数:12
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