Fragment-to-Lead Medicinal Chemistry Publications in 2021

被引：24

作者：

Walsh, Louise ^{[1
]}

Erlanson, Daniel A. ^{[2
]}

de Esch, Iwan J. P. ^{[3
]}

Jahnke, Wolfgang ^{[4
]}

Woodhead, Andrew ^{[1
]}

Wren, Ella ^{[1
]}

机构：

[1] Astex Pharmaceut, Cambridge CB4 0QA, England

[2] Frontier Med, South San Francisco, CA 94080 USA

[3] Vrije Univ Amsterdam, Amsterdam Inst Mol Med & Syst AIMMS, Div Med Chem, NL-1081 HZ Amsterdam, Netherlands

[4] Novartis Inst Biomed Res, Chem Biol & Therapeut, CH-4002 Basel, Switzerland

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 66卷 / 02期

关键词：

MAT2A INHIBITOR; DISCOVERY; POTENT; DESIGN; EFFICIENCY;

D O I：

10.1021/acs.jmedchem.2c01827

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This Perspective is the seventh in an annual series that summarizes successful Fragment-to-Lead (F2L) case studies published in a given year. A tabulated summary of relevant articles published in 2021 is provided, and features such as target class, screening methods, and ligand efficiency are discussed, both for the 2021 examples and for the combined examples over the years 2015-2021. In addition, trends and new developments in the field are summarized. In particular, the use of structural information in fragment-based drug discovery is discussed.

引用

页码：1137 / 1156

页数：20

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