The tooth: A marker of developmental abnormalities

被引：0
|
作者：
de La Dure-Molla, Muriel [1 ,2 ,3 ]
Gaucher, Celine [4 ,5 ,6 ,7 ]
Dupre, Nicolas [8 ,9 ,10 ,11 ,12 ]
Zupan, Agnes Bloch [13 ,14 ,15 ,16 ]
Berdal, Ariane [8 ,9 ,10 ,11 ,12 ]
Chaussain, Catherine [4 ,17 ,18 ,19 ]
机构：
[1] Hop Rothschild, AP HP, Ctr Reference Malad Rares Orales & Dent, O Rares, Paris, France
[2] Univ Paris Cite, Inst Imagine, Inserm, UMR1163,UFR Oodontol,Bases Mol & Physiopathol Oste, Paris, France
[3] FHU DDS Paris Net, European Reference Network CRANIO, Filiere TETECOU, Paris, France
[4] Univ Paris Cite, AP HP, Inserm, FHU DDS Paris Net, Paris, France
[5] Univ Paris Cite, UFR Odontol, Lab BRIO URP2496, Paris, France
[6] Hop Henri Mondor, AP HP, Serv Med Buccodent, Creteil, France
[7] Ctr Univ Paris Cite, Hop Cochin, AP HP, Serv Med Gen Malad Rares Syst & Organe, Montrouge, France
[8] Univ Paris Cite, FHU DDS Paris Net, AP HP, Inserm, Paris, France
[9] Sorbonne Univ, Univ Paris Cite, Ctr Rech Cordeliers, Inserm,U1138,Equipe Physiopathol Orale Mol, Paris, France
[10] Univ Paris Cite, UFR Odontol, Paris, France
[11] Hop Rothschild, AP HP, Ctr Reference Malad Rares O Rares, Paris, France
[12] European Reference Network CRANIO, Filiere TETECOU, Paris, France
[13] Univ Strasbourg, CNRS, UMR7104, Inserm,U1258,Inst Genet & Biol Mol & Cellulaire IG, Illkirch Graffenstaden, France
[14] Fac Chirurg Dent Robert Frank, Strasbourg, France
[15] Inst Etud Avancees USIAS, Strasbourg, France
[16] Hop Univ Strasbourg HUS, Hop Civil, Ctr Reference Malad Rares Orales & Dent O Rares, Pole Med & Chirurg Buccodent,European Reference Ne, Strasbourg, France
[17] Lab BRIO URP2496, UFR Odontol, Paris, France
[18] Hop Bretonneau, AP HP, Paris, France
[19] European Reference Network BOND, Ctr Reference Malad Rares Metab Calcium Phosphate, Filiere OSCAR, Paris, France
来源：
M S-MEDECINE SCIENCES | 2024年 / 40卷 / 01期
关键词：
AMELOGENESIS-IMPERFECTA; GENETIC-DISORDERS; MUTATIONS; ENAMEL; PROTEINS; BONE;
D O I：
10.1051/medsci/2023190
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Tooth formation results from specific epithelial-mesenchymal interactions, which summarize a number of developmental processes. Tooth anomalies may thus reflect subclinical diseases of the kidney, bone and more broadly of the mineral metabolism, skin or nervous system. Odontogenesis starts from the 3(rd) week of intrauterine life by the odontogenic orientation of epithelial cells by a first PITX2 signal. The second phase is the acquisition of the number, shape, and position of teeth. It depends on multiple transcription and growth factors (BMP, FGF, SHH, WNT). These ecto-mesenchymal interactions guide cell migration, proliferation, apoptosis and differentiation ending in the formation of the specific dental mineralized tissues. Thus, any alteration will have consequences on the tooth structure or shape. Resulting manifestations will have to be considered in the patient phenotype and the multidisciplinary care, but also may contribute to identify the altered genetic circuity.
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页码：16 / 23
页数：8
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