This paper mainly introduces the application and progress of the time-varying gravity in earthquake research in the Chinese Mainland. Since the Xingtai earthquake in 1966, China has begun mobile gravity monitoring, trying to explore the relationship between gravity changes and seismic activities. The gravity changes before and after the Haicheng M (S)7.3 earthquake in 1975 and the Tangshan M (S)7.8 earthquake in 1976 were observed. In 1981, a high-precision metal spring gravimeter was introduced to carry out high-precision mobile gravity observation in the key earthquake monitoring areas in western Yunnan. The gravity anomaly changes near the epicenters of the Lijiang M (S)7.0 earthquakes in 1996 were observed. In 1998, a high-precision absolute gravity survey was introduced to carry out the overall scale gravity field monitoring in the Chinese Mainland, and the large-scale gravity change information before Wenchuan M (S)8.0 and Yutian M (S)7.3 earthquakes in 2008 was obtained, and the effective prediction opinions were given. After the Wenchuan M (S)8.0 earthquake in 2008, the integration of the national network and the regional network accelerated, forming the whole gravity observation network in the Chinese Mainland, which made a relatively successful medium-term prediction for a series of earthquakes with M (S)6.0 or above (such as Lushan M (S)7.0, Menyuan M (S)6.4, and Jiuzhaigou M (S)7.0) in recent years and played an important role in the study of the earthquake mechanism and earthquake prediction level in China. Finally, the existing problems in time-varying gravity monitoring in China are pointed out, and the prospect of earthquake research using time-varying gravity monitoring data is put forward.