Extracorporeal circulation models in small animals: beyond the limits of preclinical research

被引：4

作者：

Kayumov, Mukhammad ^{[1
,2
,3
]}

Habimana, Reverien ^{[3
,4
]}

Kim, Dowan ^{[2
,3
]}

Obiweluozor, Francis O. ^{[2
,3
]}

Jeong, In Seok ^{[2
,3
]}

Cho, Hwa Jin ^{[3
,5
]}

机构：

[1] Chonnam Natl Univ, Dept Med Sci, Grad Sch, Gwangju, South Korea

[2] Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Thorac & Cardiovasc Surg, Med Sch, Gwangju, South Korea

[3] Chonnam Natl Univ Hosp, Extracorporeal Circulat Res Team, Gwangju, South Korea

[4] Chonnam Natl Univ, Med Sch, Dept Biomed Sci, Grad Sch, Gwangju, South Korea

[5] Chonnam Natl Univ, Childrens Hosp, Dept Pediat, Med Sch, Gwangju, South Korea

来源：

ACUTE AND CRITICAL CARE | 2023年 / 38卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

cardiopulmonary bypass; extracorporeal circulation; extracorporeal membrane oxygenation; experimental research; review; RAT CARDIOPULMONARY BYPASS; INFLAMMATORY RESPONSE; MEMBRANE OXYGENATORS; SUPPORT; INJURY; ARREST;

D O I：

10.4266/acc.2023.00381

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Extracorporeal membrane oxygenation (ECMO) use has remarkably increased in recent years. Although ECMO has become essential for patients with refractory cardiac and respiratory failure, extracorporeal circulation (ECC) is associated with significant complications. Small-animal models of ECC have been developed and widely used to better understand ECC-induced pathophysiology. This review article summarizes the development of small-animal ECC models, including the animal species, circuit configuration, priming, perioperative procedures, cannulation, and future perspectives of small-animal ECMO models.

引用

页码：1 / 7

页数：7

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