Design, synthesis and biological evaluation of aryl amino derivatives of pyrido [3,2-d]pyrimidines as anticancer agents

被引：1

作者：

Syeda, Arshiya Banu ^{[1
]}

Syeda, Asra Banu ^{[2
]}

Ferazoddin, Mohammad ^{[1
]}

Paul, J. P. ^{[1
]}

Syed, Tasqeeruddin ^{[3
]}

Juluru, Bhasker ^{[1
]}

机构：

[1] Chaitanya, Dept Chem, Hanamkonda, Telangana, India

[2] Jazan Univ, Dept Chem, Jazan, Saudi Arabia

[3] King Khalid Univ, Coll Pharm, Dept Pharmaceut Chem, Abha, Saudi Arabia

来源：

SYNTHETIC COMMUNICATIONS | 2023年 / 53卷 / 17期

关键词：

Afatinib; canertinib; pyrido[3; 2-d]pyrimidine and anticancer properties; quinazoline; KINASE INHIBITORS; UTILITY; CANCER;

D O I：

10.1080/00397911.2023.2229926

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new bunch of substituted aryl amino derivatives structurally modified pyrido[3,2-d]pyrimidines (10a-j) have been synthesized and evaluated for anticancer effects against PC3 (human prostate), A549 (human lung), MCF-7 (human breast) and Colo-205 (human colon) cancer cell lines by utilizing of MTT procedure. Most of the synthesized compounds were showed anticancer activity good to moderate activities with IC50 values range from 0.013 & PLUSMN; 0.0058 & mu;M to 8.22 & PLUSMN; 5.87 & mu;M, whereas, standard 9 etoposide used as standard drug) showed IC50 values from 0.14 & PLUSMN; 0.017 & mu;M to 3.08 & PLUSMN; 0.135 & mu;M, respectively. Among the synthesized compounds, five compounds 10a, 10b, 10c, 10d and 10e demonstrated more potent activity on all cell lines. Mainly, compound 10e displayed higher anticancer activity.

引用

页码：1426 / 1438

页数：13

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