Direct Synthesis of Disubstituted 3-Isoquinolinone Derivatives through the Construction of C-N, C=O, and C(sp2)-C(sp3) Bonds under Transition-Metal-Free Conditions

被引：11
|
作者：
Shi, Jianyi [1 ]
Chen, Xia [1 ]
Huang, Jingyun [1 ]
Lu, Yantong [1 ]
Yang, Zhendong [1 ]
Zhong, Mingli [2 ]
Zhu, Zhongzhi [1 ]
Chen, Xiuwen [1 ]
机构：
[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China
[2] Guilin Med Univ, Pharmacol Lab Prevent & Treatment High Incidence D, Guilin 541199, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 26卷 / 03期
基金：
中国国家自然科学基金;
关键词：
acetophenone; dearomatization; nitromethane; trifunctionalization; CATALYZED HYDROXYLATION; EFFICIENT SYNTHESIS; ARYL HALIDES; FUNCTIONALIZATION; ISOQUINOLINES; OXIDATION; PHENOLS;
D O I：
10.1002/ejoc.202201231
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The efficient three-component cascade coupling reaction of 3-haloisoquinolines, haloalkanes, and sp(3)-carbon nucleophiles (acetophenone or nitromethane) led to a series of structurally novel 1,2-disubstituted-3-isoquinolinones through the formation of C(sp(3))-C(sp(2)), C-N, and C=O bonds. The NaOAc-promoted reaction described in this work is simple to operate, environment friendly, and highly selective.
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页数：5
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