Synergistic activity of the CDK4/6 antagonist narazaciclib (ON123300) with irreversible BTK inhibition in ibrutinib-resistant mantle cell lymphoma

被引:0
|
作者
Profitos-Peleja, Nuria
Ribeiro, Marcelo L.
Silverstein, Adar Makovski
Cosenza, Stephen
Roue, Gael
机构
关键词
D O I
10.1158/1538-7445.AM2023-5974
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5974
引用
收藏
页数:2
相关论文
共 49 条
  • [31] Cyclin D1 Driven CDK4 Activity Is Responsible for Hypersensitivity to NOXA Inducing Combination Treatment in Mantle Cell Lymphoma (MCL) Cells
    Heine, Simon
    Silkenstedt, Elisabeth
    Dengler, Michael A.
    Markus, Kleih
    Ott, German
    Carabaza, Neus Gimenez
    Dolors, Colomer
    van der Kuip, Heiko
    Aulitzky, Walter E.
    BLOOD, 2017, 130
  • [32] The CDK 4/CDK 6 Inhibitor PD0332991 significantly reduces cell growth via a G1 phase arrest in Mantle Cell Lymphoma cell lines and additively increases effects of Ibrutinib
    Zoellner, A-K
    Dietzfelbinger, R.
    Hutter, G.
    Zimmermann, Y.
    Hiddemann, W.
    Dreyling, M.
    ONKOLOGIE, 2013, 36 : 198 - 198
  • [33] The Novel CDK9/CDK4/6/PI3K Triple Inhibitor LCI139 for the Treatment of MYC-Driven Mantle Cell Lymphoma
    Pal, Dhananjaya
    Arditti, Page Mangum
    Maddeboina, Krishnaiah
    McHale, Cody C.
    Yang, Hsih-Te
    Yada, Bharath
    Dryden, Hailey Lynn
    Foureau, David M.
    Durden, Donald L.
    BLOOD, 2023, 142
  • [34] Preclinical Activity of Novel BET Protein Proteolysis Targeting Chimeras (BETP-PROTACs) and Their Combination with Venetoclax or CDK4/6 Inhibitor Against Human Mantle Cell Lymphoma (MCL) Cells
    Sun, Baohua
    Fiskus, Warren
    Raina, Kanak
    Qian, Yimin
    Crew, Andrew
    Saenz, Dyana T.
    Mill, Christopher Peter
    Nowak, Agnieszka J.
    Saenz, David N.
    Crews, Craig M.
    Bhalla, Kapil N.
    BLOOD, 2017, 130
  • [35] Induction of Early G1-Arrest by CDK4/CDK6 Inhibition Sensitizes Mantle Cell Lymphoma Cells to Selective PI3Kδ Inhibition by GS-1101 Through Enhancing the Magnitude and Duration of p-AKT Inhibition
    Chiron, David
    Martin, Peter
    Di Liberto, Maurizio
    Huang, Xiangao
    Ely, Scott A.
    Lannutti, Brian J.
    Leonard, John P.
    Mason, Christopher E.
    Chen-Kiang, Selina
    BLOOD, 2012, 120 (21)
  • [36] SENEX-mediated CDK4/6 inhibition promotes senescence and confers apoptosis resistance in B-cell non-Hodgkin lymphoma
    Wang, Jiyu
    Yi, Liuying
    Huang, Keke
    Wang, Yangyang
    Wang, Huiping
    Zhai, Zhimin
    BIOCELL, 2024, 48 (03) : 453 - 462
  • [37] Combination efficacy of HDAC inhibitor vorinostat and CDK-4/6 dual inhibitor palbociclib against therapy-resistant mantle cell lymphoma
    Chaturvedi, Nagendra K.
    Hatch, Nathan D.
    Sutton, Garrett L.
    Kling, Matthew J.
    Vose, Julie M.
    Joshi, Shantaram S.
    CANCER RESEARCH, 2017, 77
  • [38] Mutation Burden in CDKN2C, CDK1 and E2F2 Is Associated with Differential Response to Targeting CDK4/CDK6 in Combination with Bortezomib in Mantle Cell Lymphoma
    Mason, Christopher E.
    Di Liberto, Maurizio
    Huang, Xiangao
    Chiron, David
    Bretz, Jamieson
    Abdallah, Ramsey
    Ely, Scott A.
    Knowles, Daniel M.
    Martin, Peter
    Leonard, John P.
    Chen-Kiang, Selina
    BLOOD, 2011, 118 (21) : 1596 - 1596
  • [39] CDK4/6 inhibition augments anti-tumor efficacy of XPO1 inhibitor selinexor in natural killer/T-cell lymphoma
    Wang, Yali
    Chen, Jianfeng
    Gao, Yan
    Chai, Kelila Xin Ye
    Hong, Jing Han
    Wang, Peili
    Chen, Jinghong
    Yu, Zhaoliang
    Liu, Lizhen
    Huang, Cheng
    Taib, Nur Ayuni Muhammad
    Lim, Kerry May Huifen
    Guan, Peiyong
    Chan, Jason Yongsheng
    Huang, Dachuan
    Teh, Bin Tean
    Li, Wenyu
    Lim, Soon Thye
    Yu, Qiang
    Ong, Choon Kiat
    Huang, Huiqiang
    Tan, Jing
    CANCER LETTERS, 2024, 597
  • [40] CDK4/6-INHIBITION BY ABEMACICLIB INDUCES POTENT EARLY G1-ARREST IN MCL CELL LINES AND SHOWS SEQUENCE-SPECIFIC INTERACTIONS WITH CYTARABINE AND IBRUTINIB
    Fischer, L.
    Mayer, A.
    Irger, M.
    Freysoldt, B.
    Zimmermann, Y.
    Hutter, G.
    Hiddemann, W.
    Dreyling, M.
    HAEMATOLOGICA, 2017, 102 : 575 - 575