Fetuin-A levels and Insulin Resistance in Obese and Non-Obese Iraqi Children

The study's objective was to assess fetuin-A serum levels in persons with and without obesity and their potential relationships with other laboratory and clinical factors. In this case-control study, 60 obese Iraqi children (30 boys and 30 girls) participated, with 30 non-obese Iraqi children serving as the control group (15 boy, 15 girl). The subject's age ranges from nine to sixteen. Obese subjects had higher serum fetuin-A levels than lean subjects. Significant correlations were seen between greater serum fetuin-A levels and metabolic syndrome patients. In obese children with IR, there are positive correlations between Fetuin-A and SBP, DBP, weight, BMI, FBG, HOMA-IR, TG, and LDL-C, but a negative significant association with HDL-C. It can conclude that obese kids have higher fetuin-A concentrations than normal kids. These results support the idea that fetuin-A and Met S have a functionally relevant relationship in obesity and play a significant role in the pathophysiology of metabolic disease in obese children. Insulin resistance and other characteristics of the Metabolic syndrome, Significant correlations exist between fetuin-A and other factors, such as elevated BMI, elevated blood pressure, and lowered HDL-C.