Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

被引：0

作者：

Sun, Jie ^{[1
]}

Tang, Li ^{[2
]}

机构：

[1] Zhejiang Univ, Hangzhou, Peoples R China

[2] Ecole Polytech Fed Lausanne EPFL, Lausanne, Switzerland

来源：

NATURE BIOTECHNOLOGY | 2024年 / 42卷 / 11期

关键词：

Compendex;

D O I：

10.1038/s41587-023-02061-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unprecedented antitumor activity indicated by high cure rates and durable responses in mice. Clinical studies of IL-10-producing CAR T cells are underway.

引用

页码：1654 / 1655

页数：2

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