Nanoarchitectonics of versatile platform based on graphene oxide for precise and enhanced synergistic cancer photothermal-photodynamic/chemotherapy

被引：3
|
作者：
Liu, Feng [1 ]
Xu, Chengfeng [1 ]
Li, Jiale [1 ]
Zhang, Ziying [1 ]
Jin, Xiaokang [1 ]
Wang, Bing [1 ]
机构：
[1] Zhejiang Sci Tech Univ, Dept Polymer Mat, Hangzhou 310018, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2023年 / 1294卷
基金：
中国国家自然科学基金;
关键词：
Graphene oxide; Phototherapy; Chemotherapy; Synergistic therapy; DRUG-DELIVERY; NANOPARTICLES; NANOSHEETS; RESPONSES; EFFICACY; THERAPY; CELLS;
D O I：
10.1016/j.molstruc.2023.136499
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The synergy therapy possesses ultrahigh curative effect in the anti-cancer treatment. In this work, nanoscale graphene oxide (NGO) was prepared, loaded with gold nanoparticles (AuNPs) and thiol polyethylene glycol folic acid (SH-PEG1000-FA), and further modified with the photosensitizer methylene blue (MB) or the anticancer drug 5-fluorouracil (5-Fu) to obtain multifunctional nanoplatforms for photothermal-photodynamic synergy (NGO-AuNPs-FA/MB) or photothermal-chemotherapy synergy (NGO-AuNPs-FA/5-Fu), respectively. The results show that NGO-AuNPs-FA has a high drug loading rate and good biocompatibility, and the multifunctional nano -platform exhibits excellent photodynamic and photothermal properties under laser irradiation. The cell viabil-ities of NGO-AuNPs-FA/MB and NGO-AuNPs-FA/5-Fu significantly decreased under near-infrared (NIR) laser irradiation, showing excellent in vitro antitumor effects. Therefore, NGO-AuNPs-FA/MB and NGO-AuNPs-FA/5-Fu nanoplatforms achieve synergistic photothermal-photodynamic and photothermal-chemotherapy treatments, respectively, which have promising application prospects in anti-cancer treatment.
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页数：13
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