Immediate hypersensitivity reaction to intravitreal injection of triamcinolone acetonide following treatment by pars plana vitrectomy: A case report

Rationale:Hypersensitivity reactions to intravitreal injection of triamcinolone acetonide (TA) were very rare and had been infrequently reported. In this study, we reported the clinical features of hypersensitivity reactions of TA, explored its management, and analyze the relative factors. Patient concerns, diagnosis, interventions, and outcomes:We described a case of an immediate hypersensitivity reaction to intravitreal injection of TA following the treatment by pars plana vitrectomy. A 27-year-old man was reported with an immediate hypersensitivity reaction following an intravitreal injection of TA. 0.1 mL TA (40 mg/mL) was injected into the vitreous cavity and then white punctate edema appeared on the surface of the retina. Three days later, the visual acuity was 20/500 and white punctate edema disappeared on the surface of the retina without specific treatment. Conclusions and importance:Hypersensitivity reaction must be considered in cases of intravitreal injection of TA that may resolve without specific treatment. The clinical intravitreal injection of TA requires filtration to remove excipients.