Effects of centipedic acid on acute lung injury: A dose-response study in a murine model

被引：1
|
作者：
Gondim, Fladimir de Lima [1 ]
Moura, Marcelle Ferreira [1 ]
de Sousa, Allison Matias [1 ]
Ferreira, Ruth Mesquita [2 ]
Serra, Daniel Silveira [2 ]
Lima, Mary Anne Sousa [3 ]
Pimenta, Antonia Torres Avila [3 ]
Zin, Walter Araujo [4 ]
Cavalcante, Francisco Sales Avila [2 ]
机构：
[1] Univ Estadual Ceara, Inst Super Ciencias Biomed, Fortaleza, CE, Brazil
[2] Univ Estadual Ceara, Ctr Ciencia & Tecnol, Fortaleza, CE, Brazil
[3] Univ Fed Ceara, Dept Quim Organ & Inorgan, Fortaleza, Brazil
[4] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Rio De Janeiro, Brazil
来源：
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2023年 / 310卷
关键词：
Egletes viscosa; Diterpenoids; Centipedic acid; Respiratory mechanics; ALI; EGLETES-VISCOSA; MECHANICS; MICE; INFLAMMATION; DITERPENE; VOLUME;
D O I：
10.1016/j.resp.2022.103988
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Centipedic Acid (CPA), a natural diterpene from Egletes viscosa, an endemic species of the Caatinga biome, has shown antioxidant and anti-inflammatory properties. However, no report on the CPA on respiratory system mechanics has been so far advanced. We aimed to investigate the dose-response behavior of CPA on E. coli lipopolysaccharide (LPS)-triggered acute lung injury (ALI). Forty-eight C57BL/6 mice were randomly divided into six groups: control (SS), induced to ALI (LPS), 4 groups induced to ALI pre-treated with 12.5, 25, 50 and 100 mg/kg of CPA (CPA12.5, CPA25, CPA50 and CPA100 groups). CPA 100 mg/kg could prevent inflammatory cell infiltration, alveolar collapse, changes in tissue micromechanics and lung function (airway resistance, tissue elastance, tissue resistance and Static compliance). These results indicate preventive potential of this compound in the installation of ALI.
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页数：8
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