Targeting Senescent Tendon Stem/Progenitor Cells to Prevent or Treat Age-Related Tendon Disorders

被引：9
|
作者：
Wang, Hao [1 ,2 ,3 ]
Dai, Guang-Chun [1 ,2 ,3 ]
Li, Ying-Juan [1 ,2 ,3 ]
Chen, Min-Hao [1 ,2 ,3 ]
Lu, Pan-Pan [1 ,2 ,3 ]
Zhang, Yuan-Wei [1 ,2 ,3 ]
-Zhang, Ming [1 ]
Cao, Mu-Min [1 ,2 ,3 ]
Rui, Yun-Feng [1 ,2 ,3 ]
机构：
[1] Southeast Univ, Zhongda Hosp, Sch Med, Dept Orthopaed, 87 Ding Jia Qiao, Nanjing 210009, Jiangsu, Peoples R China
[2] Southeast Univ, Orthopaed Trauma Inst, 87 Ding Jia Qiao, Nanjing 210009, Jiangsu, Peoples R China
[3] Southeast Univ, Zhongda Hosp, Trauma Ctr, Sch Med, 87 Ding Jia Qiao, Nanjing 210009, Jiangsu, Peoples R China
来源：
STEM CELL REVIEWS AND REPORTS | 2023年 / 19卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Tendon aging; Tendon stem; progenitor cell; Cellular senescence; Anti-senescence therapy; INHIBITS TENOGENIC DIFFERENTIATION; HEMATOPOIETIC STEM-CELLS; OSTEOGENIC DIFFERENTIATION; SELF-RENEWAL; EXTRACELLULAR-MATRIX; COLLAGEN TURNOVER; BASIC SCIENCE; BONE LOSS; PROLIFERATION; EXPRESSION;
D O I：
10.1007/s12015-022-10488-9
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Age-related tendon disorder, a primary motor system disease, is characterized by biological changes in the tendon tissue due to senescence and seriously affects the quality of life of the elderly. The pathogenesis of this disease is not well-understood. Tendon stem/progenitor cells (TSPCs) exhibit multi-differentiation capacity. These cells are important cellular components of the tendon because of their roles in tendon tissue homeostasis, remodeling, and repair. Previous studies revealed alterations in the biological characteristics and tenogenic differentiation potential of TSPCs in senescent tendon tissue, in turn contributing to insufficient differentiation of TSPCs into tenocytes. Poor tendon repair can result in age-related tendinopathies. Therefore, targeting of senescent TSPCs may restore the tenogenic differentiation potential of these cells and achieve homeostasis of the tendon tissue to prevent or treat age-related tendinopathy. In this review, we summarize the biological characteristics of TSPCs and histopathological changes in age-related tendinopathy, as well as the potential mechanisms through which TSPCs contribute to senescence. This information may promote further exploration of innovative treatment strategies to rescue TSPCs from senescence.
引用
收藏
页码：680 / 693
页数：14
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