Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases

被引:0
|
作者
Hasan, Juiena [1 ]
Bok, Sangho [1 ]
机构
[1] Univ Denver, Ritchie Sch Engn & Comp Sci, Dept Elect & Comp Engn, Denver, CO 80208 USA
来源
BIOSENSORS-BASEL | 2024年 / 14卷 / 03期
基金
美国国家科学基金会;
关键词
plasmonics; SPR; LSPR; infectious disease; biosensors; fluorescence; INFLUENZA-A H1N1; URINARY-TRACT-INFECTIONS; ORIGINAL ANTIGENIC SIN; HEPATITIS-B-VIRUS; ENHANCED-FLUORESCENCE; EMISSION ENHANCEMENT; BIOMARKER DETECTION; IMMUNE-RESPONSES; VIRAL-HEPATITIS; T-CELLS;
D O I
10.3390/bios14030130
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The increasing demand for rapid, cost-effective, and reliable diagnostic tools in personalized and point-of-care medicine is driving scientists to enhance existing technology platforms and develop new methods for detecting and measuring clinically significant biomarkers. Humanity is confronted with growing risks from emerging and recurring infectious diseases, including the influenza virus, dengue virus (DENV), human immunodeficiency virus (HIV), Ebola virus, tuberculosis, cholera, and, most notably, SARS coronavirus-2 (SARS-CoV-2; COVID-19), among others. Timely diagnosis of infections and effective disease control have always been of paramount importance. Plasmonic-based biosensing holds the potential to address the threat posed by infectious diseases by enabling prompt disease monitoring. In recent years, numerous plasmonic platforms have risen to the challenge of offering on-site strategies to complement traditional diagnostic methods like polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISA). Disease detection can be accomplished through the utilization of diverse plasmonic phenomena, such as propagating surface plasmon resonance (SPR), localized SPR (LSPR), surface-enhanced Raman scattering (SERS), surface-enhanced fluorescence (SEF), surface-enhanced infrared absorption spectroscopy, and plasmonic fluorescence sensors. This review focuses on diagnostic methods employing plasmonic fluorescence sensors, highlighting their pivotal role in swift disease detection with remarkable sensitivity. It underscores the necessity for continued research to expand the scope and capabilities of plasmonic fluorescence sensors in the field of diagnostics.
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页数:42
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