Effect of maternal serum magnesium and calcium levels on umbilical glial fibrillary acidic protein levels in preterm labor

被引：0
|
作者：
Santoso, Dhanny Primantara Johari [1 ]
Nugrahani, Annisa Dewi [1 ]
Siddiq, Amillia [2 ]
Pramatirta, Akhmad Yogi [2 ]
Aziz, Muhammad Alamsyah [2 ]
Irianti, Setyorini [2 ]
Pribadi, Adhi [2 ]
Anwar, Anita Deborah [2 ]
Effendi, Jusuf Sulaeman [2 ]
机构：
[1] Padjadjaran State Univ, Slamet Gen Dist Hosp Garut, Dr Hasan Sadikin Gen Hosp, Fac Med,Maternal Fetal Med Div,Dept Obstet & Gynae, Pasteur 38, Bandung 40161, W Java, Indonesia
[2] Padjadjaran State Univ, Dr Hasan Sadikin Gen Hosp, Fac Med, Dept Obstet & Gynaecol,Maternal Fetal Med Div, Bandung, Indonesia
来源：
SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期
关键词：
CORD BLOOD; SULFATE; NEWBORN; WOMEN;
D O I：
10.1038/s41598-023-40022-x
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Magnesium can prevent astrocyte cell death and Glial Fibrillary Acidic Protein (GFAP) secretion as inflammatory marker in preterm delivery. This study was performed to analyze differences in umbilical cord GFAP levels in preterm labor given magnesium sulfate (MgSO4) as treatment group and control group and analyze the correlation between magnesium and calcium levels with umbilical GFAP levels. This quasi-experimental study was performed on 68 patients at Dr. Hasan Sadikin General Hospital from February-June 2021 consisting of 34 patients in each group. Maternal-umbilical cord magnesium levels, calcium levels, and GFAP levels were examined using ELISA test. The result was statistically measured by IBM SPSS 24.0. We found that there was a significant difference between maternal and umbilical magnesium levels and GFAP umbilical cord blood levels between the treatment and the control group (P < 0.05) in which GFAP level was higher in the control group. The multivariate analysis showed no significant relevance between mother magnesium and calcium level to umbilical cord GFAP level in the MgSO4 group. As conclusions, umbilical cord blood GFAP levels in preterm labor given MgSO4 were lower than in preterm deliveries who were not given MgSO4. There was no correlation between magnesium, calcium, and GFAP levels in the treatment group.
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页数：7
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