Simultaneous perfusion, diffusion, T2*, and T1 mapping with MR fingerprinting

被引:2
|
作者
Fan, Hongli [1 ,2 ]
Bunker, Lisa [3 ]
Wang, Zihan [1 ,2 ]
Durfee, Alexandra Zezinka [3 ]
Lin, Doris [2 ]
Yedavalli, Vivek [2 ]
Ge, Yulin [4 ]
Zhou, Xiaohong Joe [5 ]
Hillis, Argye E. [3 ]
Lu, Hanzhang [1 ,2 ,6 ]
机构
[1] Johns Hopkins Univ, Dept Biomed Engn, Sch Med, Baltimore, MD USA
[2] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Sch Med, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD USA
[4] NYU, Dept Radiol, Grossman Sch Med, New York, NY USA
[5] Univ Illinois, Dept Radiol, Ctr Magnet Resonance Res, Chicago, IL USA
[6] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA
基金
美国国家卫生研究院;
关键词
arterial spin labeling; arterial transit time; cerebral blood flow; diffusion; MR fingerprinting (MRF); perfusion; relaxometry; stroke; ACUTE ISCHEMIC-STROKE; HUMAN BRAIN; RESONANCE; QUANTIFICATION; MODEL; TIME;
D O I
10.1002/mrm.29880
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: Quantitative mapping of brain perfusion, diffusion, T-2*, and T-1 has important applications in cerebrovascular diseases. At present, these sequences are performed separately. This study aims to develop a novel MRI technique to simultaneously estimate these parameters. Methods: This sequence to measure perfusion, diffusion, T-2*, and T-1 mapping with magnetic resonance fingerprinting (MRF) was based on a previously reported MRF-arterial spin labeling (ASL) sequence, but the acquisition module was modified to include different TEs and presence/absence of bipolar diffusion-weighting gradients. We compared parameters derived from the proposed method to those derived from reference methods (i.e., separate sequences of MRF-ASL, conventional spin-echo DWI, and T-2* mapping). Test-retest repeatability and initial clinical application in two patients with stroke were evaluated. Results: The scan time of our proposed method was 24% shorter than the sum of the reference methods. Parametric maps obtained from the proposed method revealed excellent image quality. Their quantitative values were strongly correlated with those from reference methods and were generally in agreement with values reported in the literature. Repeatability assessment revealed that ADC, T-2*, T-1, and B-1(+) estimation was highly reliable, with voxelwise coefficient of variation (CoV) <5%. The CoV for arterial transit time and cerebral blood flow was 16%3% and 25%+/- 9%, respectively. The results from the two patients with stroke demonstrated that parametric maps derived from the proposed method can detect both ischemic and hemorrhagic stroke. Conclusion: The proposed method is a promising technique for multi-parametric mapping and has potential use in patients with stroke.
引用
收藏
页码:558 / 569
页数:12
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