One-pot multicomponent green synthesis of novel series of 4-hydroxy-2-pyridone-fused spiropyrans catalyzed by acetic acid

被引：2

作者：

Kamali, Mahmood ^{[1
,2
]}

Ebrahimi, Asadollah ^{[1
]}

机构：

[1] Kharazmi Univ, Fac Chem, Dept Organ & Polymer Chem, Tehran, Iran

[2] Kharazmi Univ, Fac Chem, Dept Organ & Polymer Chem, Tehran 1571914911, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2023年 / 53卷 / 17期

关键词：

4-Hydroxy-pyridine-2-one; isatin; multicomponent reaction; ninhydrin; spiropyran; 2-AMINO-4H-CHROMENE DERIVATIVES; 3-COMPONENT SYNTHESIS; NATURAL-PRODUCTS; EFFICIENT; DISCOVERY; FACILE; 2-AMINO-4H-PYRANS; SPIROOXINDOLES; APOPTOSIS; DRUGS;

D O I：

10.1080/00397911.2023.2230504

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot multicomponent reaction is reported for synthesizing a novel series 4-hydroxy-2-pyridone-fused spiropyran through the reaction of 4-hydroxy-6-methylpyridine-2-ones alkaloids, malononitrile or ethyl cyanoacetate, and ninhydrin or isatin derivatives. The optimized conditions for this reaction were obtained in ethanol solvent, acetic acid as catalyst, ambient temperature (for ninhydrin) or 70 & DEG;C (for isatin), and 8 hr reaction time. Mild and safe conditions, easy work-up and separation, high to excellent yields, and eco-compatibility are the main advantages of this synthesis for affording potentially bio-effective novel products.

引用

页码：1439 / 1450

页数：12

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