Long-term economic evaluation of the recombinant Mycobacterium tuberculosis fusion protein (EC) test for the diagnosis of Mycobacterium tuberculosis infection

被引:2
|
作者
Diao, Sha [1 ,2 ,3 ,4 ]
Liu, Zheng [1 ,2 ,3 ,4 ,5 ]
Liu, Dan [1 ,2 ,3 ,4 ,6 ]
Cheng, Xiao [1 ,2 ,3 ,4 ]
Zeng, Linan [1 ,2 ,3 ,4 ]
Jiao, Xue-Feng [1 ,2 ,3 ,4 ]
Chen, Zhe [1 ,2 ,3 ,4 ,6 ]
Ni, Xiaofeng [1 ,2 ,3 ,4 ]
He, Siyi [1 ,2 ,3 ,4 ,6 ]
Wu, Bin [7 ]
Kang, Deying [8 ]
Wan, Chaomin [4 ,9 ]
Zhao, Rongsheng [10 ]
Wang, Huiqing [11 ]
Zhang, Lingli [1 ,2 ,3 ,4 ,8 ]
机构
[1] Sichuan Univ, West China Univ Hosp 2, Dept Pharm, Chengdu, Peoples R China
[2] Sichuan Univ, West China Univ Hosp 2, Evidence Based Pharm Ctr, Chengdu, Peoples R China
[3] NMPA Key Lab Tech Res Drug Prod Vitro & Vivo Corr, Chengdu, Peoples R China
[4] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Minist Educ, Chengdu, Peoples R China
[5] Sichuan Univ, West China Sch Med, Chengdu, Peoples R China
[6] Sichuan Univ, West China Sch Pharm, Chengdu, Peoples R China
[7] Shanghai Jiao Tong Univ, Renji Hosp, Dept Pharm, Sch Med, Shanghai, Peoples R China
[8] Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu, Peoples R China
[9] Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China
[10] Peking Univ Third Hosp, Dept Pharm, Beijing, Peoples R China
[11] Sichuan Univ, West China Univ Hosp 2, Med Simulat Ctr, Chengdu, Peoples R China
关键词
recombinant Mycobacterium tuberculosis fusion protein (EC); purified protein derivative of tuberculin (TB-PPD); Mycobacterium tuberculosis infection; decision tree-markov model; cost-utility; RURAL CHINA; MULTICENTER; MANAGEMENT; RISK;
D O I
10.3389/fphar.2023.1161526
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Tuberculosis continues to be a significant global burden. Purified protein derivative of tuberculin (TB-PPD) is one type of tuberculin skin test (TST) and is used commonly for the auxiliary diagnosis of tuberculosis. The recombinant Mycobacterium tuberculosis fusion protein (EC) test is a new test developed in China.Objective: Evaluate the long-term economic implications of using the EC test compared with the TB-PPD test to provide a reference for clinical decision-making.Methods: The target population was people at a high risk persons of being infected with Mycobacterium tuberculosis. The outcome indicator was quality-adjusted life years (QALY). A cost-utility analysis was used to evaluate the long-term economic implications of using the EC test compared with the TB-PPD test. We employed a decision tree-Markov model from the perspective of the whole society within 77 years.Results: Compared with the TB-PPD test, the EC test had a lower cost but higher QALY. The incremental cost-utility ratio was -119,800.7381 CNY/QALY. That is, for each additional QALY, the EC test could save 119,800.7381 CNY: the EC test was more economical than the TB-PPD test.Conclusion: Compared with the TB-PPD test, the EC test would be more economical in the long term for the diagnosis of M. tuberculosis infection according our study.
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页数:8
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