The Role of the Piezo1 Mechanosensitive Channel in the Musculoskeletal System

被引：18

作者：

Dienes, Beatrix ^{[1
]}

Bazso, Tamas ^{[2
]}

Szabo, Laszlo ^{[1
,3
]}

Csernoch, Laszlo ^{[1
,3
]}

机构：

[1] Univ Debrecen, Fac Med, Dept Physiol, H-4032 Debrecen, Hungary

[2] Univ Debrecen, Fac Med, Dept Orthoped, H-4032 Debrecen, Hungary

[3] ELKH DE Cell Physiol Res Grp, H-4032 Debrecen, Hungary

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 07期

关键词：

mechanosensitive channels; Piezo1; Yoda1; calcium homeostasis; skeletal muscle; cartilage; bone; tendon; ligament; joint; ACTIVATED ION-CHANNEL; REGULATES BONE HOMEOSTASIS; MECHANICAL STIMULATION; SATELLITE CELLS; PROTEIN; MECHANOTRANSDUCTION; STRESS; ATP; INACTIVATION; CYTOSKELETON;

D O I：

10.3390/ijms24076513

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the recent discovery of the mechanosensitive Piezo1 channels, many studies have addressed the role of the channel in various physiological or even pathological processes of different organs. Although the number of studies on their effects on the musculoskeletal system is constantly increasing, we are still far from a precise understanding. In this review, the knowledge available so far regarding the musculoskeletal system is summarized, reviewing the results achieved in the field of skeletal muscles, bones, joints and cartilage, tendons and ligaments, as well as intervertebral discs.

引用

页数：20

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