Regulation of metabolism in pancreatic ductal adenocarcinoma via nanotechnology-enabled strategies

被引：8
|
作者：
Wang, Zhiqin [1 ,2 ,3 ]
Wu, Bowen [2 ,3 ,4 ]
Nie, Guangjun [2 ,3 ,5 ]
Wei, Jingyan [1 ]
Li, Yiye [2 ,3 ]
机构：
[1] Jilin Univ, Coll Pharmaceut Sci, Changchun 130021, Peoples R China
[2] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
[3] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
[4] Zhengzhou Univ, Sch Basic Med Sci, Zhengzhou 450001, Peoples R China
[5] GBA Natl Inst Nanotechnol Innovat, Guangzhou 510530, Peoples R China
来源：
CANCER LETTERS | 2023年 / 560卷
基金：
中国国家自然科学基金;
关键词：
Pancreatic ductal adenocarcinoma; Tumor metabolism; Nanomedicine; Drug delivery; LACTATE-DEHYDROGENASE; CANCER PROGRESSION; TUMOR-CELLS; GEMCITABINE; THERAPY; METFORMIN; PROMOTES; GROWTH; NANOMEDICINE; ACCUMULATION;
D O I：
10.1016/j.canlet.2023.216138
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with insidious onset and early distal metastasis. Metabolic reprogramming, the autonomous changes in cellular bioenergetics driven by aberrant genetic events and crosstalk between cancer and non-cancer cells in the desmoplastic microenvironment, is pivotal for the rapid progression of PDAC. As an attractive therapeutic target, nucleoside metabolism is regulated by various anti-metabolic drugs for the clinical treatment of PDAC. Despite various challenges, such as poor drug delivery efficiency and off-target side effects, metabolic modification and intervention are emerging as promising strategies for PDAC therapy, enabled by the rapid development of nanotechnology-based drug delivery strate-gies. In this review, we discuss the metabolic characteristics of PDAC and highlight how the development of nanomedicine has boosted the development of new therapeutics for PDAC by modulating critical targets in metabolic reprogramming.
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收藏
页数：11
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