Phosphine-Catalyzed [3+2] Cycloaddition of Aza-Aurones and Allenoates: Enantioselective Synthesis of 2-Spirocyclopentyl-Indolin-3-Ones

被引：3

作者：

Brambilla, Elisa ^{[1
]}

Pozza, Camilla ^{[1
]}

Rizzato, Silvia ^{[2
]}

Abbiati, Giorgio ^{[1
]}

Pirovano, Valentina ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Sci Farmaceut, Sez Chim Gen & Organ A Marchesini, Via G Venezian 21, I-20133 Milan, Italy

[2] Univ Milan, Dipartimento Chim, Via C Golgi 19, I-20133 Milan, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 26卷 / 03期

关键词：

asymmetric catalysis; cycloaddition; organocatalysis; phosphanes; spiro compounds; SUBSTITUTED ALLENOATES; ASYMMETRIC-SYNTHESIS; ANNULATION REACTION; NITRILE IMINES; BREVIANAMIDE-A; REGIOSELECTIVITY; ALKALOIDS; MECHANISM; ALLENES;

D O I：

10.1002/ejoc.202201385

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective phosphine-catalyzed [3+2] cycloaddition between aza-aurones and allenoates is here described. The reaction proceeded under mild reaction conditions to afford 2-spirocyclopentyl indolin-3-one derivatives as single gamma-isomer and with high levels of stereocontrol.

引用

页数：5

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